Association of Phosphate Supplements With Refeeding Oedema in Restrictive Eating Disorders.

Objective: Refeeding oedema, believed to result from the effects of insulin on renal sodium retention and subsequent oedema formation, typically occurs during the first 2 weeks after reintroduction of nutrition in individuals with severe malnutrition and can intensify body image distress in patients with eating disorders (EDs). Phosphate supplements have been found to increase insulin sensitivity, and it is hypothesised that they may also contribute to refeeding oedema in patients with EDs.

Method: In this retrospective cohort study of 633 patients with severe malnutrition due to anorexia nervosa (AN) or avoidant restrictive food intake disorder (ARFID), the impact of phosphate supplementation on the rate of weight gain was investigated.

Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUS spinal motor neurons.

Mutations in the gene ( ) are among the most frequently occurring genetic forms of amyotrophic lateral sclerosis (ALS). Early pathogenesis of -ALS involves impaired DNA damage response and axonal degeneration. However, it is still poorly understood how these gene mutations lead to selective spinal motor neuron (MN) degeneration and how nuclear and axonal phenotypes are linked.

The Evolving Role of Neoadjuvant Radiation Therapy in Pancreatic Adenocarcinoma.

Background/objectives: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers. Surgical resection is the most reliable chance for cure, but high rates of positive margins and local failure persist. Neoadjuvant therapies (NAT), including chemotherapy and radiation therapy (RT), are being explored to improve surgical outcomes, particularly in borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC).