Effect of Chemically Transformed Macrocyclic Polyene Antibiotics on Tumor Cells.

Comparative analysis of the effects of chemically transformed polyene antibiotics pimaricin, nystatin, lucensomycin, amphotericin B, and levorin on biological objects in vivo and in vitro revealed the greatest biological activity of original amphotericin B and levorin with its derivatives. The study also examined the effects of alkyl derivatives of amphotericin B and levorin modified in certain parts of the lactone ring on the lipid and biological membranes. It is established that methylated levorin possesses larger biological activity than the original antibiotic.

[Ways of reducing mortality in injuries of the heart].

Based on an analysis of literature and 45 personal observations the authors make a conclusion that reduction of lethality following wounds of the heart can be reached by introducing certain changes into traditional approaches to the problem. In order to approximate the moment of medical aid to the victims thoracotomy for the liquidation of heart tamponade, arrest of bleeding should be performed at the place of accident or in the admission department of the hospital, even to the detriment of traditional requirements of asepsis. For the prevention and treatment of early and late complications the patients must be directed to specialized centers (thoracal departments of the hospitals).

[The submolecular structure of the Carnation Mottle virus].

The model of the tertiary structure of the CMtV subunit was suggested and the mode of its packaging into the capsid was determined on the basis of electron microscopy small-angle X-ray scattering and X-ray diffraction data. The i-ray diffraction data on the crystal of the native virion of Carnation Mottle Virus were obtained on the automatic diffractometer supplied with two-dimensional detector.