Publications by authors named "V Kennedy"
Insulin resistance, stem cell dysfunction, and muscle fiber dystrophy are all age-related events in skeletal muscle (SKM). However, age-related changes in insulin isoforms and insulin receptors in myogenic progenitor satellite cells have not been studied. Since SKM is an extra-pancreatic tissue that does not express mature insulin, we investigated the levels of insulin receptors (INSRs) and a novel human insulin upstream open reading frame (INSU) at the mRNA, protein, and anatomical levels in Baltimore Longitudinal Study of Aging (BLSA) biopsied SKM samples of 27-89-year-old (yrs) participants.
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- The study aimed to evaluate how otitis media with effusion (OME) progresses in children under 12 who do not have hearing loss.
- Nineteen observational studies were analyzed, revealing that the resolution rates of OME varied widely over time, from 10% to 99% by 12 months, with significant differences based on the population and the criteria for resolution.
- Although there was a trend of improved resolution and recurring cases over longer follow-up, the results did not show a consistent pattern, indicating that varied populations and definitions played a role.
Objective: To systematically assess the modifiable risk factors for developing otitis media with effusion (OME) in children under 12 years.
Methods: We searched Embase, MEDLINE, INAHTA database, CENTRAL, CDSR and Epistemonikos for cohort studies with ≥40 children per arm/prognostic factor, published in English from 2000 to November 2022. We assessed risk of bias using the Quality in Prognosis Studies checklist, and overall evidence quality was assessed using Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.
Article Synopsis
- The objective of the study was to evaluate the natural history of hearing loss related to otitis media with effusion (OME) in children under 12 years old.
- A comprehensive search of multiple medical databases identified 13 relevant studies involving different sample sizes that examined the resolution rates of OME-related hearing loss over time.
- Results showed that while OME-related hearing loss resolution improved significantly over longer follow-up periods, the rates varied considerably based on the duration of OME and the specific population studied, indicating a complex relationship and varying definitions of resolution.