Evaluation of Anticancer Activity of Novel and Tumor-Targeted Glutamine-Conjugated Organotin(IV) Compounds in Colorectal Cancer─An In Vitro and In Vivo Study.

Over the years, numerous ligand-based organotin(IV) Schiff base compounds have shown remarkable cytotoxicity and anticancer activities, but their clinical use is restricted by systemic toxicity, prompting the search for targeted therapies. Targeted delivery can be enhanced by exploiting the inherent characteristics of cancer cells such as glutamine addiction, which is essential to support cellular biosynthesis and cell growth to sustain aberrant proliferation. Our previous study revealed glutamine-conjugated organotin(IV) compounds have strong DNA/protein affinities, favorable in silico ADME profiles, and significant antiproliferative activity.

Pd@BTL-Cd core-shell nanoparticles as plasmonic photocatalysts for the reductive amination of furfural in water.

This work reports the step-wise fabrication of a core-shell plasmonic nanocomposite Pd@BTL-Cd consisting of a BTL-Cd shell and a palladium nanoparticle core. BTL-Cd is the [Cd(BTL)·CdCl] complex where the heptadentate framework of the bis-compartmental ligand encapsulated two Cd(II) centres in separate pockets. Pd@BTL-Cd has been found to be highly efficient for the photocatalytic conversion of furfural (a biomass-derived aldehyde) to furfuryl amine reductive amination in aqueous ammonia at room temperature.

Immune-related adverse events not associated with survival in advanced or metastatic gastroesophageal cancers.

Immune checkpoint inhibitors (ICIs) have shown promise in the treatment of gastric and oesophageal cancers (GEC). Despite their promising efficacy, ICIs have been associated with unique side effects known as immune-related adverse events (IRAEs). Several studies have shown improved treatment responses in patients with IRAEs compared to those without IRAEs in various cancer types such as melanoma and non-small cell lung cancer.

Comparative Study on Giving Feedback to MBBS Students by Two Different Techniques in Biochemistry in a Medical College in North India.

Background: Delivering feedback to students who have just joined a new course is relevant for it may help them to understand their subject better and hence enhance their performance.

Aim: The present study aimed to provide feedback to students using two different techniques: the sandwich method and the Ask-Tell-Ask method. It also evaluated students' perceptions of the feedback and assessed the quality of the feedback provided.

A New Source of Opioid and Lead Toxicity on the Block-Kamini: An Emerging Health Hazard-A Case Series.

Introduction: Illicit drug abuse with opioids can inadvertently lead to refractory anemia and lead poisoning. The absence of adequate regulations for Ayurvedic herbal products has led to the adulteration of opioid-containing drugs with lead. As a result, lead toxicity has become a concern within this seldom-addressed population of opioid users.