Lymphocyte nucleoli activation and changes of the mononuclear phagocytic system in mice during 3-methylcholanthrene carcinogenesis.

After an intra-muscular application of 3-methylcholanthrene (MCA) in a dose of 0.2 mg/animal to SPF mice, strain C57B1/10, changes in the lymphocyte nucleoli activation (LNA) and changes of the mononuclear phagocytic system (MPS) in blood and tissues were monitored. The tests were carried out after the first and sixth weeks of the MCA administration, when the tumours were not yet palpable, and 12 weeks after the MCA injection, when the tumours were manifest in 100% of animals.

Effects of 226Ra and X-irradiation on the proliferative and differentiative ability of mouse hemopoietic stem cells.

The ability of hemopoietic stem cells to repopulate spleens of heavily irradiated syngeneic hosts in form of macroscopically visible clonal colonies of differentiating cells was studied in mice exposed for 32 and 4 weeks to internally deposited 226Ra (0.56 and 0.46 muCi per mouse respectively) or to 100 rad X-irradiation.

3H-TDR labelling of osteoprogenitor cells after 226RA incorporation in mice.

The time course of 3H-TDR labelling index of osteoprogenitor cells and the doses in endosteum of lumbar vertebra and distal femoral epiphysis were autoradiographically determined in young female mice after single injections of 19.7 and 55.9 micronCi/kg body weight of 226Ra.

Planimetric evaluation and comparison of roentgenograms of osteogenic sarcomas induced by 226Ra and 224Ra in mice.

Osteosarcomas were induced in mice by three activities of 226Ra (8.8 micronCi, 24.6 micronC and 70.