Publications by authors named "V K Tanwar"
Article Synopsis
- Aging reflects a decline in the effectiveness of natural selection with age; the antagonistic pleiotropic theory suggests that aging arises from trade-offs that enhance early growth and reproduction, although human evidence is limited.
- Using Mendelian Randomization, the research found that later ages of menarche and childbirth are linked to longer parental lifespan, reduced frailty, slower epigenetic aging, later menopause, and a lower risk of age-related diseases.
- The study identified 128 genetic variants related to age-related outcomes, connecting early reproductive years with significantly higher risks of diseases like type 2 diabetes, heart disease, and obesity, thus supporting the antagonistic pleiotropy theory.
Objectives: Spinal degenerative disorders are a major cause of morbidity in the elderly resulting in high dependency. Most of them have a trend to be managed conservatively considering age, comorbidities, and apprehensions of surgical complications. Surgical intervention at early stage with appropriate indications can have better outcomes rather than conservative management in fit patients.
View Article and Find Full Text PDFBackground: Obesity and diabetes are associated with elevated free fatty acids like palmitic acid (PA), which promote chronic inflammation and impaired inflammation resolution associated with cardiometabolic disorders. Long noncoding RNAs (lncRNAs) are implicated in inflammatory processes; however, their roles in PA-regulated inflammation and resolution are unclear.
Methods: We performed RNA-sequencing analysis to identify PA-regulated coding genes and novel lncRNAs in CD14 monocytes from healthy volunteers.
Autologous fat grafting for the correction of cicatricial ectropion.
J Plast Reconstr Aesthet Surg
December 2022
Background: Cicatricial ectropion can be corrected by invasive surgical modalities such as full-thickness skin graft, lateral tarsal strip procedure, etc., which are associated with donor site morbidity and additional scars. Use of autologous fat graft (AFG) in treatment of burn scars has previously shown encouraging clinical results as to skin color, texture, and softness.
View Article and Find Full Text PDFThe purpose of this study was to compare and correlate disease activity score including 28 joints counts (DAS-28) Squeeze with DAS-28 and clinical disease activity index (CDAI) to assess disease activity (DA) in rheumatoid arthritis (RA) patients. A total of 100 RA patients were included in the study. All subjects were evaluated for disease activity using the DAS-28 Squeeze, DAS-28, and CDAI.
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