Publications by authors named "V K Saka"
This cross-sectional study aimed to investigate the role of peak inspiratory flow rate (PIFR) in the management of inhalation therapy for patients with chronic obstructive pulmonary disease (COPD). Conducted in the Department of Pulmonary Medicine at a tertiary care institute from July 2021 to January 2022, this study included a total of 351 patients who were clinically diagnosed with stable COPD and currently receiving inhaler therapy. Participants underwent comprehensive assessments that included demographic data collection, the use of the ABCD assessment tool to evaluate disease severity, the COPD Assessment Test (CAT) for quality of life measurement, and assessments for adherence to inhaler therapy and inhaler technique proficiency.
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- Oxidative stress and inflammation are key issues in immune-compromised diseases and cancer treatments, prompting a study on the immune-boosting effects of Bryonia alba (BA) in mice with induced immune deficiency.
- The research involved treating BALB/c mice with various potencies of BA after cyclophosphamide administration, resulting in significant improvements in immune parameters like RBC and WBC levels, and increased expression of important immune cytokines.
- Histopathology showed that BA-treated mice maintained healthy spleen structures compared to those damaged by cyclophosphamide, suggesting BA's potential as an effective immunostimulant during chemotherapy, but more studies are needed on its effects against immune-compromised infections.
Article Synopsis
- This study explored how homeopathic remedies (RT) at different concentrations (6C, 30C, and 200C) can enhance the immune system of BALB/c mice that were weakened by the anticancer drug cyclophosphamide (CPM).
- The administration of CPM caused significant deficiencies in key blood cell levels and compromised immune organs, while RT treatment, especially at 200C, significantly improved these metrics and restored immune function.
- The research indicates that RT could potentially be beneficial as an immunostimulant therapy, but more studies in other immunocompromised contexts are necessary before considering application in human clinical trials.
Background: Camphora officinarum (CO) is a commonly used homeopathic remedy for treating colds, collapse, and recurrent eruptive illnesses.
Objective: Due to the non-availability of safety data on CO, the current study intended to determine the oral toxicity of CO in its ethanol-potentized dilutions 6C, 30C, and 200C in Wistar albino rats as per OECD guidelines.
Materials And Methods: A single oral dose of CO-6C, 30C, and 200C (2000 µl/kg) was administered, and the animals were monitored for behavior and mortality for up to 14 days in an acute toxicity study.
Article Synopsis
- The study explored differences in neutrophil lymphocyte ratio (NLR) and platelet indices between stable chronic obstructive pulmonary disease (COPD) patients and those experiencing acute exacerbation of COPD (AECOPD).
- Conducted at Jawaharlal Institute of Postgraduate Medical Education and Research, the research involved 64 subjects (32 with stable COPD and 32 with AECOPD) and analyzed blood samples to identify variations.
- Results showed that NLR, platelet distribution width, ESR, and C-reactive protein levels were significantly higher in AECOPD patients, indicating a correlation between these inflammatory markers and the severity of the condition.