Publications by authors named "V K Nikolenko"
Updates on Intrinsic Medicinal Chemistry of 1,4-dihydropyridines, Perspectives on Synthesis and Pharmacokinetics of Novel 1,4-dihydropyrimidines as Calcium Channel Blockers: Clinical Pharmacology.
Curr Top Med Chem
January 2025
Background: Several chemical studies described the physiological efficacy of 1,4- dihydropyridines (DHPs). DHPs bind to specific sites on the α1 subunit of L-type calcium channels, where they demonstrate a more pronounced inhibition of Ca2+ influx in vascular smooth muscle compared to myocardial tissue. This selective inhibition is the basis for their preferential vasodilatory action on peripheral and coronary arteries, a characteristic that underlies their therapeutic utility in managing hypertension and angina.
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- Metastatic brain tumors commonly cause vasogenic edema, which can impact patient prognosis, but there is limited research on its diagnostic significance.
- This study analyzed MRI data from 60 patients to investigate the correlation between the edema/tumor index (ETI) and tumor histopathology based on the 2021 WHO classification.
- Results showed that although malignant tumors had larger edema volumes, the ETI didn't significantly correlate with histopathological grades, and ROC analysis indicated ETI wasn't a reliable predictor for malignancy.
Recent developments in Achilles tendon risk-analyzing rupture factors for enhanced injury prevention and clinical guidance: Current implications of regenerative medicine.
J Orthop Translat
November 2024
Article Synopsis
- Many countries have increased focus on physical education and sports, yet there's been a notable rise in injuries, particularly Achilles tendon ruptures, which make up 47% of such cases.
- The review aims to identify risk factors for Achilles tendon ruptures and propose personalized prevention strategies based on extensive database research.
- It highlights non-modifiable factors like genetics and age as well as modifiable factors such as nutrition and exercise habits, emphasizing the importance of early treatment and the latest advancements in injury management.
Incidence of liver cancer as one of the most common cancers worldwide and become the significant contributor for the mortality among cancer patients. The disease burden, risk factors, and trends in incidence and mortality of liver cancer globally was described subsequently estimated the projections of liver cancer incidence or mortality by 2040. Data regarding age-standardized incidence and mortality rates for liver cancer was obtained from multiple databases, including GLOBOCAN 2020, CI5 volumes I-XI, WHO mortality database, and Global Burden of Disease (GBD)-2019.
View Article and Find Full Text PDFBackground: Hematopoiesis within the bone marrow (BM) is a complex and tightly regulated process predominantly influenced by immune factors. Aging, diabetes, and obesity are significant contributors to BM niche damage, which can alter hematopoiesis and lead to the development of clonal hematopoiesis of intermediate potential (CHIP). Genetic/epigenetic alterations during aging could influence BM niche reorganization for hematopoiesis or clonal hematopoiesis.
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