[The entropic function and radioprotective effectiveness of N-substituted S-2-aminoethylthiosulfates].

Within the framework of an informational approach and the statistical method of comparison of qualitative parameters, a systemic factor is proposed, that is, the difference between entropy functions of hydrogen and carbon in the molecular structure that permits to reliably distinguish highly radioprotective agents among a series of drugs. A limiting factor (hydrophobicity) that restricts the manifestation of radioprotective properties of potential radioprotectors is considered. A relationship between toxic properties of the protective agents and their structure is discussed.

[Relation between the electron and information factors and the radioprotective effectiveness of sulfur-containing compounds].

There is a simple relationship between the radioprotective effectiveness of sulfur-containing preparations and chemical structure of the compounds. It is established that the administration of the protector to the organism is just as effective as introduction of certain portion of information which should exceed some threshold for the effective radioprotectors.

[Effect of electron and steric interactions on the radioprotective properties of indolylalkylamines].

Molecular mechanisms of radioprotective action of some substituted indolylalkylamines are discussed in terms of the statistical correlation analysis. It was established that electron and steric properties of the substituents are the factors influencing the radioprotective efficiency of these compounds. It was shown that the correlation obtained, relating the structure of the compounds to the radioprotective effect, may be applied in studies of the mechanism of action of the preparations and for the purposeful synthesis of new compounds.

[Statistical aspects of the relation of the radioprotective action of mercaptoethylamine derivatives and analogs to their electron parameters].

Numerous S-containing substances were used to study the radioprotective efficiency of the preparations depending on their microscopic characteristics. The method of statistical comparison of the qualitative parameters was used to show that the energy parameters were the most informative electron characteristics of the molecules. Each of these parameters correlated with the physicochemical processes induced in a biological system by ionizing radiation.