A Comparison of the Functional Outcome in PHILOS (Proximal Humerus Internal Locking System) Versus Proximal Humerus Interlocking Nail in Proximal Humerus Fractures.

Background Proximal humerus fractures (PHFs) are often injuries that occur in the field of orthopedics and can either be treated conservatively or operatively. The PHILOS (Proximal Humerus Interlocking System) and the proximal humerus nail (PHN) are the commonly used operative techniques. Objectives The objective of this study is to analyse the functional outcome of the PHILOS (Proximal Humerus Internal Locking System) and the PHN (Proximal Humerus Nail) in proximal humerus fractures.

Self-Transcendence as a Risk and Resilience Factor in Individuals at Clinical High Risk for Psychosis.

Aim: Self-transcendence is a personality feature and psychological resource that involves feelings of connectedness with the universe, all of humanity, and the individual self. Self-transcendence has been positively associated with both positive psychotic symptoms and clinical high risk for developing psychosis status, but studies reporting these findings focus solely on the connectedness-with-universe aspect of self-transcendence. The broader self-transcendence literature, which also includes connection with humanity and oneself, robustly supports self-transcendence as an indicator of well-being.

Unlocking the potential: integrating phytoconstituents and nanotechnology in skin cancer therapy - A comprehensive review.

Skin carcinoma, which includes basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, is influenced by various factors such as genetic predisposition, chemical exposures, immune system imbalances, and ultraviolet (UV) radiation. This review delves into the mechanisms behind the development of these cancers, exploring the therapeutic potential of microbial, plant derived compounds and nanoparticles in advancing skin cancer treatments. Special attention is given to the cytotoxic effects of anti-neoplastic agents from microbial sources on different cancer cell lines, particularly melanoma.

The Negative Symptom Inventory-Psychosis Risk (NSI-PR): Psychometric Validation of the Final 11-Item Version.

Background And Hypotheses: The lack of psychometrically validated assessment tools designed specifically to assess negative symptoms in individuals at clinical high risk (CHR) for psychosis represents a significant barrier to the early identification and prevention of psychosis. To address this need, the Negative Symptom Inventory-Psychosis Risk (NSI-PR) was developed based on the iterative, data-driven approach recommended by the National Institute of Mental Health consensus conference on negative symptoms.

Study Design: This manuscript reports the results of the second study phase that psychometrically validates the final 11-item version of the scale in data collected across 3 sites.