Ebrotidine versus ranitidine in the treatment of acute duodenal ulcer. A multicentre, randomized, double-blind, controlled clinical trial.

A total of 478 patients with endoscopically confirmed duodenal ulcer entered this randomized, parallel, double-blind trial. Patients were randomly assigned to receive ebrotidine (N-[(E)-[[2-[[[2-[(diaminomethylene)amino]- 4-thiazolyl]methyl]thio]ethyl]amino]methylene]-4-bromo-benzenesulfona mid e, CAS 100981-43-9, FI-3542) 400 mg or ranitidine 300 mg tablets (4:1) respectively, administered in single evening doses. Endoscopy, clinical examination and symptom assessment were performed at baseline and at weeks 4 and 8.

[Treatment of peptic ulcer with sucralfate].

Sucralfate made in Bulgaria (Farmaphim) and its Yugoslavian analogue venter have been tried in gastroduodenal ulcer. The drugs were given per os (1 g, 1 tablet) 4 times a day before meals for 20 days. Sucralfate treatment was assigned to 26 patients with gastric and 26 with duodenal ulcer.

[Multiple gastric aspiration biopsies combined with endoscopic and histomorphological studies].

The study includes 50 patients with duodenal peptic ulcer who are classified into 2 groups: 1 gr. of 30 patients to whom biopsy was performed twice at a 14 day interval in order to study the reproducibility of the method in relation to the histological diagnosis; II group of 20 patients served for determination of the percentage of full value biopsies suitable for diagnosis. The results showed that the histological diagnosis based on the second examination coincided with the diagnosis from the first examination in 78% of the cases and by the single examination 33% of the biopsies showed gastritis of different severity from the rest.

[Effect of a single dose of Pharmachim cimetidine on the pH of the stomach].

The effect of Cimetidine (Pharmachim), tablets of 200 mg on pH of the stomach was studied in 30 patients with active duodenal ulcer via two-electrode pH-metric probe. The drug effect could be seen from the summed up pH-gram of the patients. pH increase (p less than 0.

[Treatment of stomach ulcer with the Bulgarian preparation Farmaxolon].

Thirty-four patients with gastric ulcer were treated with the new Bulgarian preparation pharmaxolon-Pharmachim, for 20 days under clinical conditions. A favourable effect on the clinical symptoms by the pharmaxolon treatment was established but the differences with the control placebo group were statistically insignificant. A total of 47.