Publications by authors named "V K Kimiskidis"
Introduction/aims: Risdiplam was the first orally administered drug approved to treat spinal muscular atrophy (SMA). Efficacy in adults is based on short-term observational studies. This longitudinal study aimed to examine risdiplam's efficacy and safety in adults over a long period of follow-up.
View Article and Find Full Text PDFArticle Synopsis
- Clinical studies on repetitive transcranial magnetic stimulation (rTMS) show inconsistent results, possibly due to differences in study methods, prompting a review of preclinical rTMS protocols in mice for epilepsy research.
- A comprehensive search identified 23 relevant studies that used various epilepsy induction methods and defined motor thresholds, exploring the effects of different rTMS frequencies on seizure activity.
- Findings indicate that low-frequency rTMS (≤5 Hz) generally suppresses seizures and improves behavioral outcomes, while high-frequency rTMS (≥5 Hz) had mixed effects, highlighting the importance of stimulation frequency in optimizing clinical applications for epilepsy treatment.
: Developmental and epileptic encephalopathy refers to a group of conditions where patients experience abnormal development due to various causes as well as frequent epileptiform discharges that ultimately contribute, in an independent and additive fashion, to cognitive and linguistic impairments. The language and cognition outcome of these patients in adulthood has been understudied. This paper aims to present a scoping review of linguistic abilities in adults with developmental and epileptic encephalopathy to determine the extent to which language outcomes in adulthood and their relation to cognitive outcomes have been studied.
View Article and Find Full Text PDFArticle Synopsis
- Hearing impairment can be masked by neurological disorders like Temporal Lobe Epilepsy (TLE), affecting communication and mental health.
- A systematic review evaluated tools for assessing auditory processing deficits in TLE patients, revealing significant differences from normal controls in both behavioral and electrophysiological tests.
- The findings highlight the necessity of assessing hearing efficiency first, as incomplete peripheral hearing evaluations can lead to misinterpretation of auditory processing capabilities.
Background: The use of patient-reported outcomes (PRO) in clinical practice is gaining increasing attention. This study aimed to provide a critical assessment of the current state-of-the-art and beliefs about the use of PRO in the management of people with epilepsy across some European countries.
Methods: Structured interviews were conducted with European experts to collect insights about (I) the personal experience with PRO; (II) the value and impact of PRO in the decision-making process at the national level; and (III) the interest for and use of PRO by national health authorities.