[Electrophysiological and morphohistochemical study of adrenalectomy on the hippocampal neurons].

Chronic insufficiency of adrenal hormones is a pathology leading to brain dysfunction. In electrophysiological studies, by extracellular recording of spike activity of single hippocampal neurons (HN) caused by high-frequency stimulation of the entorhinal cortex (EC) in rats with unilateral removal of adrenal (adrenalectomy - AE), we analyzed mechanisms of adaptation of neural networks to chronic hormonal deprivation. The balance of excitatory and inhibitory responses, recorded in HN of intact rats was submitted to characteristic changes in dynamics of development of neurodegeneration: the dominating in norm inhibitory responses were decreased at all AE terms (from 42 % to 25 % by the 18th week).

[Borderline mental disorders in parkinsonism patients and their drug correction].

70 patients with vascular parkinsonism (VP) were investigated. The total group of patients was divided into several groups depending upon: a) the forms of disease (with typical or atypical forms of disease), b) the different syndromes (with bradykinesia and rigidity or tremor). Borderline psychic disorders manifested as a light depression with cognitive disturbances and personality changes.

[Experience with amysil treatment of patients with vascular parkinsonism].

The results of treatment of 45 patients with vascular parkinsonism are reported. To the majority of the patients, daily amysil administration (1-2 mg 2-4 times a day) was prescribed. Most pronounced was the drug effect in patients with combined syndromes in which predominated bradikynesia (79.

[Features of affective disorders in patients with vascular parkinsonism].

Depression and anxiety were revealed in 40 of 56 patients with vascular parkinsonism; irritability up to dysphoria was observed in 29 patients. The treatment included administration of DOPA drugs (nakom and madopar) and cholinolytics (benactyzin, methylbenactyzin). No clear-cut correlation was found between the severity of neurological and affective disorders either before or during the treatment.

[Method of treating parkinsonism with metamizil in combination with galanthamine (clinico-experimental basis)].

Using experimental models of parkinsonism, imitating the hypertonus of the parasympathetic system (hypokinesia, rigidity and tremor) following the intraperitoneal injection of the acetylcholinesterase inhibitor galanthamin (15 mg/kg) to mice, the authors showed that the m-cholinoblocker metamisyl (2 mg/kg) blocks all manifestations of the CNS parasympathetic hypertonus whereas the n-cholinoblocker eterofen (30 mg/kg) increases them. Based on the theory developed by the authors as to the reciprocity of interaction between the m- and n-cholinergic mechanisms within the framework of the single cholinergic system of the body, they offered the treatment of parkinsonism by the combined use of metamisyl (1-2 mg) and galanthamin (5-10 mg). Forty-five patients were treated with metamisyl alone and 40 patients with metamisyl coupled with galanthamin.