Publications by authors named "V K Hansen"
Absorption cross section of gas phase isoprene in the infrared-visible range.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
We have recorded the gas phase spectrum of isoprene at room temperature from the mid-infrared range and into the visible range (600 cm to 17050 cm). Absorption spectra were obtained by Fourier transform infrared, conventional dispersion ultraviolet-visible-near-infrared and cavity ring-down spectroscopy to cover the entire range with a resolution comparable to that of the instruments on the James Webb Space Telescope. We have assigned the CH-stretching fundamental and overtone bands corresponding to the Δv=1-6 transitions based on anharmonic vibrational calculations using normal mode and local mode models, for the lower- and higher-energy regions, respectively.
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- The cartilage growth plate is vital for skeletal growth, but its postnatal homeostasis mechanisms are not well understood; research highlights the role of ADGRG6/GPR126 in maintaining the growth plate structure and function in mice.
- Deletion of the Adgrg6 gene disrupts growth plate balance, leading to issues like a shorter resting zone and altered chondrocyte behavior, with implications on signaling molecules like PTHrP and Indian Hedgehog.
- ADGRG6 is shown to be crucial for chondrocyte health and regulation, impacting genes involved in growth and cell death, particularly through enhancing the expression of SOX9 and maintaining overall growth plate integrity.
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- The study aimed to identify the maximum tolerated dose (MTD) for treating muscle invasive bladder cancer using image-guided adaptive radiation therapy while monitoring long-term clinical outcomes.
- A total of 59 patients with specific stages of bladder cancer participated, with their tumors receiving doses ranging from 68 to 72 Gy, and the MTD was found to be 70 Gy.
- Results showed that 5-year overall survival was 58%, and the bladder preservation rate was high at 89%, with minimal severe acute toxicities reported.
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- Radiotherapy trial quality assurance (RT QA) is essential for ensuring safe and consistent radiation treatment across different institutions, focusing on adaptive methods like Image-Guided Radiotherapy (IGRT) in the RAIDER trial for bladder cancer.
- This study analyzed data from 72 participants over 884 Cone-Beam Computed Tomography (CBCT) scans to compare online and offline treatment plan selections, revealing an overall concordance rate of 83%.
- Results showed an improvement in concordance from 75% in the first stage of the trial to 91% in the second stage, emphasizing the importance of ongoing QA support during the introduction of new radiotherapy techniques.
Previous theoretical investigations of the reactions between an OH radical and a nucleobase have stated the most important pathways to be the C5-C6 addition for pyrimidines and the C8 addition for purines. Furthermore, the abstraction of a methyl hydrogen from thymine has also been proven an important pathway. The conclusions were based solely on gas-phase calculations and harmonic vibrational frequencies.
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