Publications by authors named "V K Eshwara"
Introduction: Gut pathogen colonization, where pathogens disrupt the normal gut microbiota, has been implicated in the development of bloodstream infections (BSIs). This study investigates the association between gut pathogen colonization and BSI, hypothesizing that species causing BSI primarily originated from gut.
Methods: A prospective cohort study was conducted in the neonatal intensive care unit (NICU) of tertiary care hospital in Karnataka, India, from January 2021 to September 2023.
Article Synopsis
- The D-PRISM study investigated global practices for diagnosing and treating pneumonia in ICU settings, focusing on community-acquired, hospital-acquired, and ventilator-associated pneumonia across different countries.
- A survey gathered responses from 1,296 ICU clinicians across 72 countries, revealing varied diagnostic processes and a lack of standardized microbiological testing, particularly in lower-income regions.
- Findings indicated that the typical antibiotic treatment duration was 5-7 days, with shorter durations linked to effective antimicrobial stewardship programs in higher-income countries.
Background: Melioidosis, attributable to the soil-dwelling bacterium , stands as a paramount global health challenge, necessitating extended courses of antibiotics. While murine studies identified the gut microbiota as a modulator of bacterial dissemination during melioidosis, the human intestinal microbiota during melioidosis remains uncharacterized. Here, we characterized gut microbiota composition and antimicrobial resistance (AMR) genes at diagnosis, during treatment, and postdischarge for melioidosis.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on understanding community-acquired sepsis in lower middle-income countries like India, highlighting the influence of tropical infections and microbiology on the condition's causes and outcomes.
- - Conducted from December 2018 to September 2022, the research involved over 1000 patients admitted to an ICU, revealing a median age of 55 years and significant mortality rates, particularly among those from rural areas and working in primary sectors.
- - Findings indicated that sepsis cases often stemmed from tropical and viral infections, with notable resistance to common antibiotics, underscoring the need for targeted public health strategies in India and contributing to global sepsis research.
Background: This study aimed to assess the potential of serum interleukin-6 (IL-6) as a diagnostic marker in predicting bacteremia and to determine its association with severity and outcome among sepsis patients.
Materials And Methods: A prospective observational study was conducted, comprising a cohort of 118 patients admitted to the ICU with suspected sepsis from January 2019 to April 2020.
Results: Among the 108 patients analyzed, 60 (55.