Publications by authors named "V K Chopra"
Mechanisms coupling the mTOR pathway to chronic obstructive pulmonary disease (COPD) pathogenesis.
Cytokine Growth Factor Rev
January 2025
Chronic Obstructive Pulmonary Disease (COPD) is a poorly reversible respiratory disorder distinguished by dyspnea, cough, expectoration and exacerbations due to abnormality of airways or emphysema. In this review, we consider the therapeutic potential of targeting Mammalian target of Rapamycin (mTOR) for treating COPD. The mTOR is a highly conserved serine-threonine protein kinase that integrates signals from growth factors and nutrients to control protein synthesis, lipid biogenesis and metabolism.
View Article and Find Full Text PDFBackground: New catheter materials for peripherally inserted central catheters (PICCs) may reduce the risk of device failure due to infectious, thrombotic, and catheter occlusion events. However, data from randomized trials comparing these catheters are lacking.
Methods: We conducted a randomized, controlled, superiority trial in three Australian tertiary hospitals.
Aims: In the EMPACT-MI trial, empagliflozin reduced heart failure (HF) hospitalizations but not mortality in acute myocardial infarction (MI). Contemporary reports of clinical event rates with and without type 2 diabetes mellitus (T2DM) in acute MI trials are sparse. The treatment effect of empagliflozin in those with and without T2DM in acute MI is unknown.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how much time Japanese clinical residents spend at patients' bedsides and its potential impact on their exam scores.
- A nationwide survey included over 5,300 first- and second-year residents, revealing that 66.9% spent less than 60 minutes per day at the bedside.
- Results indicated a positive correlation between increased time-at-bedside (especially categories C2, C3, and C5) and higher General Medicine In-Training Examination scores, while categories C4 and C6 showed no significant association.
Introduction: Nudges, or low-effort interventions aimed at influencing behaviour, can improve provider medical decision-making through promoting adherence to practice guidelines. Strengthening provider-patient humanistic connection through nudges may increase provider satisfaction, mitigate burnout and improve patient satisfaction and outcomes. This scoping review aims to map the literature investigating provider-directed, low-effort interventions aimed at enhancing the provider-patient connection.
View Article and Find Full Text PDF