Publications by authors named "V Joukov"

Assembled genome sequences are being generated at an exponential rate. Here we present FCS-GX, part of NCBI's Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes. FCS-GX screens most genomes in 0.

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Article Synopsis
  • FCS-GX is a new tool developed by NCBI to quickly identify and remove contamination from genomic sequences.
  • It efficiently screens genomes in a short time (0.1-10 minutes) and has high sensitivity (>95%) and specificity (>99.93%) for detecting various contaminant species.
  • The tool was used to analyze 1.6 million GenBank assemblies, uncovering 36.8 Gbp of contamination, which led to improved genome accuracy in NCBI's databases.
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Background: Biomedical researchers use alignments produced by BLAST (Basic Local Alignment Search Tool) to categorize their query sequences. Producing such alignments is an essential bioinformatics task that is well suited for the cloud. The cloud can perform many calculations quickly as well as store and access large volumes of data.

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Background: Biomedical researchers use alignments produced by BLAST (Basic Local Alignment Search Tool) to categorize their query sequences. Producing such alignments is an essential bioinformatics task that is well suited for the cloud. The cloud can perform many calculations quickly as well as store and access large volumes of data.

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The National Center for Biotechnology Information (NCBI) is an archive providing free access to a wide range and large volume of biological sequence data and literature. Staff scientists at NCBI analyze user-submitted data in the archive, producing gene and SNP annotation and generating sequence alignment tools. NCBI's flagship genome browser, Genome Data Viewer (GDV), displays our in-house RefSeq annotation; is integrated with other NCBI resources such as Gene, dbGaP, and BLAST; and provides a platform for customized analysis and visualization.

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