Publications by authors named "V Jimenez-Zepeda"
In the evaluation of a patient's primary hematologic malignancy, positron emission tomography/computed tomography (PET/CT) imaging may incidentally detect a concerning abnormality suggestive of a second concurrent cancer. Despite accounting for nearly 10% of all cancers diagnosed in Canada, there has yet to be a systematic review focused on the prevalence and significance of these incidental PET/CT findings in the context of primary hematologic malignancies. As such, a systematic search strategy was employed on MEDLINE and Embase to document the prevalence and clinical significance of incidental PET/CT findings suggestive of a second concurrent cancer detected in patients evaluated for their primary hematologic malignancy.
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- Tafamidis is an expensive treatment for transthyretin amyloidosis cardiomyopathy (ATTR-CM) that shows positive outcomes, but predicting long-term effectiveness remains challenging.
- A study analyzed 139 ATTR-CM patients to identify baseline factors, such as age and renal function, linked to mortality and hospitalization, regardless of whether they received tafamidis.
- Key findings suggest that factors like renal function and frailty are critical indicators of adverse outcomes in ATTR-CM patients, which can help in better assessing treatment eligibility.
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- Pre-clinical studies indicated that adding doxycycline to treatments could benefit patients with AL amyloidosis, but a recent trial found no improvement in progression-free survival when doxycycline was added to the CyBorD regimen.
- This study aimed to investigate the effectiveness of doxycycline alongside bortezomib-containing regimens (BCRs) in newly diagnosed AL amyloidosis patients, particularly those with cardiac issues, compared to patients receiving BCR alone.
- The results showed that there was no significant difference in treatment outcomes, such as overall response rates and time to response, between the groups receiving BCR alone and those receiving BCR with doxycycline (BCR-D).
In patients with multiple myeloma (MM), the presence of high-risk cytogenetic abnormalities is associated with worse disease control and survival. Autologous stem cell transplant (ASCT) does benefit these patients. Tandem transplantation has been explored as a means to deepen responses and further improve survival however, its role remains controversial.
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