Comparison of the Performance of Artificial Intelligence Versus Medical Professionals in the Polish Final Medical Examination.

Background: The rapid development of artificial intelligence (AI) technologies like OpenAI's Generative Pretrained Transformer (GPT), particularly ChatGPT, has shown promising applications in various fields, including medicine. This study evaluates ChatGPT's performance on the Polish Final Medical Examination (LEK), comparing its efficacy to that of human test-takers.

Methods: The study analyzed ChatGPT's ability to answer 196 multiple-choice questions from the spring 2021 LEK.

A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy.

In the mammalian hippocampus, adult-born granule cells (abGCs) contribute to the function of the dentate gyrus (DG). Disruption of the DG circuitry causes spontaneous recurrent seizures (SRS), which can lead to epilepsy. Although abGCs contribute to local inhibitory feedback circuitry, whether they are involved in epileptogenesis remains elusive.

Nonradioactive in situ hybridization. A rapid approach for the identification of marker chromosomes: study of a case of acute leukemia with a Yq specific DNA probe.

Nonradioactive in situ hybridization provides a rapid method for detecting specific nucleic acid sequences. In this study of a patient with acute leukemia, we applied in situ hybridization for identification of a marker chromosome and determination of the number of copies of this marker in interphase nuclei using a biotinylated Yq-specific DNA probe (pY3.4).

Lymphocyte subpopulation profiles and mitogen kinetics in immunological deficiency testing.

The correlation between lymphocyte proliferative responses to mitogens and T4/T8 ratios was analyzed in a cross section of patients who either were in a high-risk group for HTLV-III infection or fulfilled clinical criteria for acquired immune deficiency syndrome (AIDS). The patient results showed that, correlated with decreased T4/T8 ratios, there was a decrease in mitogen responsiveness first to pokeweed mitogen (PWM), followed by concanavalin A (Con A) and then phytohemagglutinin (PHA). Parallel to this decrease there was a shift toward higher concentrations of mitogens needed for optimal proliferation.

An acquired Robertsonian translocation in prolymphocytic leukemia: a case presentation and review.

Robertsonian translocations between the acrocentric autosomes are the most common type of constitutional chromosome rearrangement in humans. However, Robertsonian translocations are very rarely acquired in cancer cells. We report a patient with prolymphocytic leukemia and an acquired Robertsonian translocation in the leukemic cells.