Publications by authors named "V Jacquemin"
Article Synopsis
- In October 2020, dostarlimab, a programmed death-1 inhibitor, was granted early access in France for treating advanced endometrial cancer based on the GARNET trial results and later approved by the European Medicines Agency in April 2021.
- A real-world analysis from November 2020 to June 2021 included data from 87 eligible patients who received at least one dose of dostarlimab, showcasing a disease control rate of 56% and an overall response rate of 35%, aligning with clinical trial findings.
- The study emphasized the urgent need for new treatment options for patients post-platinum in France and noted ongoing research into the efficacy and safety of dostarlim
Background: Renal operational tolerance is a rare and beneficial state of prolonged renal allograft function in the absence of immunosuppression. The underlying mechanisms are unknown. We hypothesized that tolerance might be driven by inherited protein coding genetic variants with large effect, at least in some patients.
View Article and Find Full Text PDFBackground: Congenital hydrocephalus is characterized by ventriculomegaly, defined as a dilatation of cerebral ventricles, and thought to be due to impaired cerebrospinal fluid (CSF) homeostasis. Primary congenital hydrocephalus is a subset of cases with prenatal onset and absence of another primary cause, e.g.
View Article and Find Full Text PDFThough heterogeneity of cancers is recognized and has been much discussed in recent years, the concept often remains overlooked in different routine examinations. Indeed, in clinical or biological articles, reviews, and textbooks, cancers and cancer cells are generally presented as evolving distinct entities rather than as an independent heterogeneous cooperative cell population with its self-oriented biology. There are, therefore, conceptual gaps which can mislead the interpretations/diagnostic and therapeutic approaches.
View Article and Find Full Text PDFBackground: Primary microcephaly (PM) is defined as a significant reduction in occipitofrontal circumference (OFC) of prenatal onset. Clinical and genetic heterogeneity of PM represents a diagnostic challenge.
Methods: We performed detailed phenotypic and genomic analyses in a large cohort (n = 169) of patients referred for PM and could establish a molecular diagnosis in 38 patients.