Publications by authors named "V J Ruggiero"
Introduction: Depressive symptoms are associated with alterations in central and autonomic nervous system activity, including misperception of bodily activity (e.g., low interoception), somatic symptoms and decreased vagally mediated heart rate variability (vmHRV).
View Article and Find Full Text PDFCarbonyl-carbonyl interactions in peptides and proteins attracted considerable interest in recent years. Here, we report a survey of carbonyl-carbonyl interactions in cyclic peptides, depsipeptides, peptoids and discuss the relationship between backbone torsion angles and CO∙∙∙CO distances. In general, φ values in the range between -40° and -90° and between 40° and 90° correspond to CO∙∙∙CO distances below 3.
View Article and Find Full Text PDFCDKL5 is a kinase with relevant functions in correct neuronal development and in the shaping of synapses. A decrease in its expression or activity leads to a severe neurodevelopmental condition known as CDKL5 deficiency disorder (CDD). CDD arises from CDKL5 mutations that lie in the coding region of the gene.
View Article and Find Full Text PDFArticle Synopsis
- Progranulin is a growth factor crucial for embryonic development and maintaining tissue health, but its deficiency is linked to serious brain disorders like frontotemporal dementia.
- While low levels are problematic in the brain, high levels of progranulin are found in various cancers, suggesting it could be useful for cancer diagnosis and prognosis.
- In cancer, progranulin promotes tumor growth and invasion by interacting with signaling pathways, particularly through the EphA2 receptor, but the detailed mechanisms of how it functions in different cancer types are still being researched.
Purpose: It is well known that interferon-α (IFN-α), used for long time as the main therapy for HCV-related disease, induces thyroid alterations, but the impact of the new direct-acting antivirals (DAAs) on thyroid is not established. Aim of this prospective study was to evaluate if DAAs therapy may induce thyroid alterations.
Methods: A total of 113 HCV patients, subdivided at the time of the enrollment in naïve group (n = 64) and in IFN-α group (n = 49) previously treated with pegylated interferon-α and ribavirin, were evaluated for thyroid function and autoimmunity before and after 20-32 weeks of DAAs.