Publications by authors named "V J Quagliarello"
In this single-center observational study of 118 older adults with advanced cancer who developed non-ventilator hospital-acquired pneumonia, prolonged antibiotic durations (8-14 and ≥15 vs ≤7 d) were not associated with reduced adjusted odds of 90-day all-cause readmission or death. These data may inform antimicrobial stewardship efforts in palliative care settings.
View Article and Find Full Text PDFBackground: Older adults with advanced cancer are exposed to antibiotics but estimates of adverse drug events associated with antibiotic therapy are lacking.
Aim: Evaluate the association of antibiotic therapy with adverse drug events in older adults with advanced cancer.
Design: Cohort study where the exposure was the ratio of days of therapy of an oral or intravenous antibiotic per patient-day and the outcome was an adverse drug event, defined as cardiotoxicity, hepatotoxicity, nephrotoxicity, infection, or new detection of a multidrug-resistant organism.
Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer.
Antimicrob Steward Healthc Epidemiol
September 2022
Article Synopsis
- In a study involving 124 older adults with advanced cancer hospitalized for pneumonia, 7.3% were diagnosed with postobstructive pneumonia.
- There were no significant differences in treatment outcomes such as length of antibiotic therapy, antibiotic types, readmission rates at 30 and 90 days, or mortality between patients with and without postobstructive pneumonia.
- Bacterial infections were identified in 5 patients who had postobstructive pneumonia.
Human immunodeficiency virus (HIV) affects more than 37 million people globally, and in 2020, more than 680,000 people died from HIV-related causes. Recently, these numbers have decrease substantially and continue to reduce thanks to the use of antiretroviral therapy (ART), thus making HIV a chronic disease state for those dependent on lifelong use of ART. However, patients with HIV have an increased risk of developing some type of cancer compared to patients without HIV.
View Article and Find Full Text PDFBackground: Antimicrobial use during end-of-life care of older adults with advanced cancer is prevalent. Factors influencing the decision to prescribe antimicrobials during end-of-life care are not well defined.
Aim: To evaluate factors influencing medicine subspecialists to prescribe intravenous and oral antimicrobials during end-of-life care of older adults with advanced cancer to guide an educational intervention.