Publications by authors named "V J L Winnepenninckx"
Basal cell carcinoma (BCC) is the most frequently diagnosed form of skin cancer, and its incidence continues to rise, particularly among older individuals. This trend puts a significant strain on health care systems, especially in terms of histopathologic diagnostics required for Mohs micrographic surgery (MMS), which is used to treat BCC in sensitive locations to minimize tissue loss. This study aims to address the challenges in BCC detection within MMS whole-slide images by developing and evaluating a deep learning model that bridges weakly supervised learning with interpretable segmentation-based methods through attention maps.
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- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with increasing rates in the US and Europe, primarily linked to the Merkel cell polyomavirus (MCPyV), although its cell of origin is still uncertain.
- - The study introduced MCPyV antigens into different cancer cell lines to analyze how they affect DNA methylation and gene expression, revealing that MCPyV-LT alters DNA methylation in both cell lines while MCPyV-sT only impacted one.
- - Findings indicate significant changes in gene expression patterns, particularly in MCC13 cells, with downregulated genes in immune pathways suggesting potential targets for new immunotherapies for MCC, along with confirmation that MCPyV-LT regulates gene
Worldwide, the incidence of renal cell carcinoma (RCC) is rising, accounting for approximately 2% of all cancer diagnoses and deaths. The etiology of RCC is still obscure. Here, we assessed the presence of HPyVs in paraffin-embedded tissue (FFPE) resected tissue from patients with RCC by using different molecular techniques.
View Article and Find Full Text PDFPrevious studies have indicated a potential role of diet in the pathogenesis of renal cell carcinoma (RCC). Recently, circular bovine meat and milk factor (BMMF) DNAs have been identified in peritumoral tissues of human colon and breast cancers. Here, we investigated the prevalence of the DNA of these novel human pathogenic infectious agents in RCC and adjacent peritumoral renal tissues.
View Article and Find Full Text PDFAims: Inflammatory myofibroblastic tumour (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential, occurring at any age and at multiple sites. Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of IMT, typically involving the abdomen. Most IMTs harbour kinase gene fusions, especially involving ALK and ROS1, but 20-30% of IMTs show no detectable translocations.
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