Publications by authors named "V J J Odekerken"
Background: Monoallelic, pathogenic STUB1 variants cause autosomal dominant cerebellar ataxia (ATX-STUB1/SCA48). Recently, a genetic interaction between STUB1 variants and intermediate or high-normal CAG/CAA repeats in TBP was suggested, indicating digenic inheritance or a disease-modifying role for TBP expansions.
Objective: To determine the presence and impact of intermediate or high-normal TBP expansions in ataxic patients with heterozygous STUB1 variants.
Article Synopsis
- Deep Brain Stimulation (DBS) effectively improves symptoms of Parkinson's disease, including tremor, bradykinesia, rigidity, and axial symptoms, by stimulating specific white matter tracts.
- A study involving 237 patients identified distinct brain tracts linked to improvements in each symptom, with tremor associated with the primary motor cortex and cerebellum, and axial symptoms linked to the supplementary motor cortex and brainstem.
- An introduced algorithm utilizes these symptom-tract connections to tailor DBS settings for individual patients, aiming to enhance treatment effectiveness based on the most impactful symptoms for each person.
Background: The effectiveness of Deep Brain Stimulation (DBS) therapy for Parkinson's disease can be limited by side-effects caused by electrical current spillover into structures adjacent to the target area. The objective of the STEEred versus RING-mode DBS for Parkinson's disease (STEERING) study is to investigate if directional DBS for Parkinson's disease results in a better clinical outcome when compared to ring-mode DBS.
Methods: The STEERING study is a prospective multi-centre double-blind randomised crossover trial.
Objectives: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) for Parkinson's disease (PD) has an ambiguous relation to speech. Speech impairment can be a stimulation-induced side effect, and parkinsonian dysarthria can improve with STN-DBS. Owing to the lack of an up-to-date and evidence-based approach, DBS reprogramming for speech impairment is largely blind and greatly relies on the physician's experience.
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