Publications by authors named "V J Gauthier"
Background: Script Concordance Tests (SCTs) represent an innovative assessment method which have been introduced in the 2024 French National Ranking Examinations (EDN). These tests compare a student's clinical reasoning with that of a panel of experts under conditions of uncertainty. Typically, the question involves the impact of new information on an initially proposed hypothesis, with answers given on a Likert scale.
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- Obesity can lead to systemic inflammation and insulin resistance, increasing the risk of type 2 diabetes (T2D) and negatively impacting bone health, with unclear differences in effects between obesity and T2D.
- The study aimed to investigate how hyperinsulinemic obesity and insulinopenic T2D affect bone structure and bone marrow adipose tissue (BMAT), while also exploring the relationship with CRAMP expression and levels.
- Mice fed a high-fat diet exhibited significant weight gain and bone deterioration, while those with insulinopenic T2D showed severe glucose intolerance and less BMAT expansion, indicating differing impacts on bone health between the conditions.
Background And Hypothesis: Cardiovascular diseases are a leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Acute kidney injury (AKI) has been increasingly recognized as a potential exacerbating factor for cardiovascular events in these patients. The CKD-REIN study aims to explore the relationship between AKI and the risk of major adverse cardiovascular events (MACE) in a cohort of CKD patients.
View Article and Find Full Text PDFWhile pancreatic adenocarcinoma (PA) incidence is increasing, especially in France, the association between pesticides and PA remains unclear. The aims of this study were to assess the spatiotemporal distribution of the incidence of PA in France between 2011 and 2021 and to determine whether pesticide exposure was associated with higher risk of PA. We employed a disease-mapping and ecological regression approach with medicoadministrative data covering 99% of the French population.
View Article and Find Full Text PDFBackground And Hypothesis: The ageing of the population with advanced chronic kidney disease (CKD) increases the complexity of care pathways. Our aim was to identify subgroups of older people according to predialysis care pathways and describe their association with early morbidity-mortality after transition to dialysis.
Methods: This study included 22,128 incident dialysis patients aged ≥ 75 years during 2009-2017 from the French nationwide registry linked to the National Health Data System.