Feeling valued at work: a qualitative exploration of allied health profession support workers.

Objectives: The aim of this study was to explore Allied Health Professions (AHP) support worker perceptions of feeling valued and to understand what factors contribute to this feeling of "value".

Design: This was a qualitative study with semi-structured interviews undertaken virtually. The data were analysed using a process of thematic analysis in order to gain an in depth understanding of the factors that affect support workers feeling "valued".

RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells.

RAB11 small GTPases and associated recycling endosome have been localized to mitotic spindles and implicated in regulating mitosis. However, the physiological significance of such regulation has not been observed in mammalian tissues. We have used newly engineered mouse models to investigate intestinal epithelial renewal in the absence of single or double isoforms of RAB11 family members: Rab11a and Rab11b.

Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes.

Differentiation of mesenchymal stem cells into adipocyte requires coordination of external stimuli and depends upon the functionality of the primary cilium. The Rab8 small GTPases are regulators of intracellular transport of membrane-bound structural and signaling cargo. However, the physiological contribution of the intrinsic trafficking network controlled by Rab8 to mesenchymal tissue differentiation has not been fully defined in vivo and in primary tissue cultures.

Gaining insight into the supportive care needs of women experiencing gynaecological cancer: A qualitative study.

Aim And Objectives: To gain insight into the supportive care needs of Western Australian women experiencing gynaecological cancer.

Background: Meeting the supportive care needs of people living with cancer is becoming increasingly important as advances in cancer treatment contribute to growing numbers of survivors. International evidence suggests between 24%-56% of women with gynaecological cancer have unmet supportive care needs and that psychological challenges, information provision and holistic care are priorities.

Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.

The effects of polarized membrane trafficking in mature epithelial tissue on cell growth and cancer progression have not been fully explored . A majority of colorectal cancers have reduced and mislocalized Rab11, a small GTPase dedicated to trafficking of recycling endosomes. Patients with low Rab11 protein expression have poor survival rates.