Publications by authors named "V Iu Valvere"

In colorectal cancer (CRC) energy metabolism research, the precancerous stage of polyp has remained rather unexplored. By now, it has been shown that CRC has not fully obtained the glycolytic phenotype proposed by O. Warburg and rather depends on mitochondrial respiration.

View Article and Find Full Text PDF
Article Synopsis
  • Hereditary breast cancer screenings frequently miss many genetic predispositions at the population level, despite being well-established.
  • A national pilot study in Estonia (2018-2021) revealed that a significant number of genetic risk variants exist among women at average risk, with 75% of at-risk breast cancer cases occurring before age 50.
  • Participants found genetic risk information valuable, and a well-coordinated project team proved effective in translating research findings into practical medical applications.
View Article and Find Full Text PDF
Article Synopsis
  • Research on mitochondrial metabolism and respiration in solid tumors is advancing, but effective methods for studying these processes remain limited.
  • A new method was developed to measure mitochondrial citrate efflux in breast cancer cell lines and human samples, revealing differences in metabolic activity and respiration rates across various cancer types.
  • The study found that aggressive breast cancer subtypes exhibited higher citrate efflux and respiration compared to less aggressive ones, highlighting the need for improved cancer models that better mimic human mitochondrial function for more successful translational research.
View Article and Find Full Text PDF

This study aimed to characterize the ATP-synthesis by oxidative phosphorylation in colorectal cancer (CRC) and premalignant colon polyps in relation to molecular biomarkers KRAS and BRAF. This prospective study included 48 patients. Resected colorectal polyps and postoperative CRC tissue with adjacent normal tissue (control) were collected.

View Article and Find Full Text PDF

We conducted quantitative cellular respiration analysis on samples taken from human breast cancer (HBC) and human colorectal cancer (HCC) patients. Respiratory capacity is not lost as a result of tumor formation and even though, functionally, complex I in HCC was found to be suppressed, it was not evident on the protein level. Additionally, metabolic control analysis was used to quantify the role of components of mitochondrial interactosome.

View Article and Find Full Text PDF