[An assessment of the efficacy of stress-protector pharmacological preparations and hyperbaric oxygenation in patients in the perioperative period].

Modulating effects of some drugs and HBO on adaptation reaction have been studied in 74 surgical patients. Investigation methods included cardiac rhythm record (statistical analysis with histogram plotting--sympathetic activity index), tcpO2, tcpCO2, SaO2, finger pulse amplitude (vasomotor tone evaluation), and evaluation of changes in arterial pressure and heart rate. The treatment included intravenous propranolol (0.

[Changes in plasma levels of lipid peroxidation products and myoglobin in patients with malignant tumors in the early postoperative period].

Changes in the levels of free myoglobin and lipid peroxidation products (hydroperoxides and malonic dialdehyde) were studied in cancer patients. Their baseline levels were found to be higher in patients with cancer of the lung, large bowel, and rectum than those in controls, which indicates higher lipid peroxidation, which led to the destabilization of cellular membranes and seems to cause baseline hypermyoglobinemia. There was a drastic rise in the levels of free myoglobin in the first 24 postoperative hours.

[Use of parenteral feeding in the multimodality treatment of Crohn's disease and nonspecific ulcerative colitis].

The paper reviews publication on the use of complete parenteral feeding in the multimodality treatment of inflammatory bowel disease. Complete parenteral feeding was performed in patients with skeletization and physical retardation, in severe diseases, in inefficiency or intolerance of conventional therapy with sulfanilamides and steroids, in those who had intestinal fistulas, as well in the preparation of patients for surgical treatment. The use of complete parenteral feeding, under the above circumstances allow one to achieve persistent remission, spontaneous healing of intestinal fistulas, elimination of abnormal metabolism, nutrition, constitution, water-electrolyte balance, to reduce a surgical risk and the incidence of postoperative complications and the length of patients' hospital stay.

[Preoperative parenteral nutrition].

The paper presents the authors' own findings and a review of papers published in the Russian and foreign periodicals in the past 20-25 years, which are dedicated to the problem of preoperative parenteral diet. The authors consider preoperative parenteral diet to be indicated in severe exhaustion and impaired intestinal tubal patency. A regimen of preoperative parenteral diet should generally last no more than 5-7 days.

[Postoperative hypermyoglobinemia. Mechanism of occurrence. Predictive value].

The time course of free myoglobin content and the rate of lipid peroxidation were simultaneously studied in cancer patients. The initial concentrations of myoglobin, hydroperoxides and malonic dialdehyde (MDA) were found to be higher than the control values, thus suggesting the increased rate of lipid peroxidation in these patients, which was responsible for destruction of cell membranes. Within the first 24 hours after surgery, there was a drastic release of myoglobin, its levels being sometimes higher in case of a complicated postoperative period than those in its smooth course.