Publications by authors named "V Ignjatovic"
Objectives: To determine if a priori standardization of outcome hemostatic definitions alone was adequate to enable useful comparison between two cohorts of pediatric extracorporeal membrane oxygenation (ECMO) patients, managed according to local practice and protocol.
Design: Comparison of two separate prospective cohort studies performed at different centers with standardized outcome definitions agreed upon a priori.
Setting: General and cardiac PICUs at the Royal Children's Hospital (RCH) in Melbourne, Australia, and the Sophia Children's Hospital (SCH) in Rotterdam, The Netherlands.
Article Synopsis
- Congenital heart disease (CHD) significantly increases the risk of thromboembolism (TE) in children, with a study finding that 33% of affected patients experienced recurrent TE within a year.
- Among the risk factors identified, immobility and the presence of central venous catheters (CVC) were strongly associated with a higher likelihood of recurrence, demonstrating the need for careful monitoring and management in this population.
- The study calls for larger multicenter research to further validate these findings and improve understanding of TE recurrence in pediatric patients with CHD.
Introduction: Thromboembolism is a complication in paediatric patients with CHD requiring cardiac surgery. Previous research has focused on post-operative thromboembolism. This study aimed to describe thromboembolism frequency before or after cardiac surgery in children with CHD.
View Article and Find Full Text PDFIntravenous direct thrombin inhibitors (DTIs) are used for thromboembolic disorders. This systematic review aims to characterize intravenous DTI agents, dosing, monitoring strategies (or use), bleeding, and mortality, in pediatric patients with acute venous thromboembolism (VTE) or heparin-induced thrombocytopenia with thrombosis (HITT). MEDLINE, Embase, and Cochrane's CENTRAL were searched from inception through July 2023.
View Article and Find Full Text PDFArticle Synopsis
- Direct oral anticoagulants (DOACs) are the preferred choice for preventing venous thromboembolism (VTE) in most patients, but their effectiveness and safety in those with severe inherited thrombophilias are not well understood.
- Current research primarily comes from small studies, and there's insufficient data on how well patients stick to their treatment plans.
- Although DOACs and vitamin K antagonists show similar effectiveness and bleeding risks for preventing VTE in these patients, caution is advised with low-dose DOACs, and more extensive studies are needed for a definitive treatment strategy.