Publications by authors named "V Iacovelli"

Background: Prostate cancer is the most common diagnosed tumor and the fifth cancer related death among men in Europe. Although several genetic alterations such as ERG-TMPRSS2 fusion, MYC amplification, PTEN deletion and mutations in p53 and BRCA2 genes play a key role in the pathogenesis of prostate cancer, specific gene alteration signature that could distinguish indolent from aggressive prostate cancer or may aid in patient stratification for prognosis and/or clinical management of patients with prostate cancer is still missing. Therefore, here, by a multi-omics approach we describe a prostate cancer carrying the fusion of TMPRSS2 with ERG gene and deletion of 16q chromosome arm.

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Objectives: A radiation-induced ureteral stricture (RIUS) is a challenging condition in urologic surgery, and the optimal surgical strategy is still a matter of debate. The aim of this study was to report post-operative outcomes of minimally invasive management of this condition from a multi-institutional cohort.

Methods: Data of patients with diagnoses of RIUS at five referral robotic centers between January 2017 and December 2022 were retrospectively analyzed.

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Article Synopsis
  • The study evaluates the effectiveness of thulium laser transurethral incision of the prostate (ThuIP) as a surgical treatment for benign prostatic obstruction (BPO) over a two-year period, focusing on patient satisfaction and retention of ejaculatory function.
  • Significant improvements were noted in urinary flow rates and quality of life scores among patients, with many reporting better outcomes at all follow-up intervals, especially at 24 months.
  • Approximately 90% of patients maintained their ability to ejaculate post-surgery, with a trifecta of successful outcomes achieved by most patients within the study timeline.
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Introduction: Crystalluria is an important indicator of renal stone recurrence. Mechanisms underlying urinary stone formation are still not fully understood and raising interests has been giving to intestinal commensal bacteria for their contribute in maintaining urinary solutes equilibrium. The aim of our phase II study was to examine the administration of potassium citrate, magnesium and probiotics in order to reduce crystalluria.

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Article Synopsis
  • - The study evaluated the effectiveness and outcomes of transperineal laser ablation (TPLA) as a treatment for localized prostate cancer in patients with low to intermediate risk over a 12-month follow-up period.
  • - A total of 24 patients participated, with various pre-and post-treatment data collected about their health status, prostate-specific antigen (PSA) levels, and urinary and sexual health.
  • - Results indicated that TPLA had a successful outcome with no recurrences in the treated area after 12 months, and patients experienced minimal pain and no incontinence following the procedure.
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