[Effect of the rhythm of administration of 1,2-dimethylhydrazine on its carcinogenic action].

The regimen of DMH treatment with the same total dose influenced the realization of its carcinogenic effect. The most extensive intestinal tumours were observed when DMH was administered once a week in a dose of 21 mg/kg of body weight. Daily treatment in a dose of 3 mg per kg results in development of a less marked malignant tumour process restricted to the colon alone.