[Gliotoxic properties of multiple sclerosis and polyradiculoneuritis serum detectable in brain organ culture].

The blood serum of patients with disseminated sclerosis and polyradiculoneuritis was tested for gliotoxic effect in organ cultures of the brain of newborn cotton rats (Sygmodon hispidus). This effect was revealed in 18 out of 25 patients with disseminated sclerosis and in 9 out of 16 patients with polyradiculoneuritis. As for other diseases the gliotoxic effect was observed only in 3 out of 41 patients examined.

[Measles cellular immunity in patients with multiple sclerosis].

The micromethod of leukocyte migration inhibition test was used to study cellular immunity in patients with multiple sclerosis (MS) to measles virus antigens and some other infectious (vaccinia virus, tuberculin) and noninfectious (brain white matter extract) antigens. In MS patients the reaction to measles antigen was weaker than in the control group, while the reactivity to the brain white matter extract was increased. As for the responses to vaccinia virus and tuberculin, these two grous did not differ statistically.