Rotavirus infection in children as of today (literature review).

Introduction: Urgency of the issue of rotavirus infection (RV) is stipulated by a special place in the structure of morbidity and mortality among young children. According to the data provided by WHO, 180 million diarrheal diseases with rotavirus etiology are registered every year. The aim of this article is to examine of current views on diagnosis and management of rotavirus infection in children.

[Diagnosis of chronic duodenal obstruction].

Arteriomesenterial compression (AMC) of a low-horizontal part of the duodenum is one of the causes of chronic duodenal obstruction (CDO). The degree of compression of this part of the duodenum was studied in 82 patients with CDO. It was revealed that distance between the aorta and superior mesenterial artery (SMA) on the level of low-horizontal part of the duodenum was less than 20 mm in the majority of cases.

[Evaluation of the efficacy of inhaled glucocorticosteroids in mild bronchial asthma].

Aim: To develop a procedure for evaluating the efficacy of antiinflammatory agents in mild persistent bronchial asthma.

Materials And Methods: 76 patients with mild bronchial asthma were given long acting theophylline. If a complete clinical and functional effect was absent, the inhaled glucocorticosteroid budesonide was added to the therapy.

Correlation between the results of glucocorticoid therapy and in vitro effect of glucocorticoids on monocytes in asthma.

The effects of glucocorticoids on monocyte morphology and function in vitro and the results of high-dose budesonide therapy in patients with non-severe bronchial asthma were analyzed. Before therapy with inhalation glucocorticosteroid (budesonide) characteristics of blood monocytes and the effects of different concentrations of prednisolone on these cells were studied in vitro by luminol-dependent chemiluminescence and computer-assisted phase-interference microscopy. High sensitivity of patients to budesonide was associated with pronounced in vitro inhibitory effect of prednisolone on monocyte activity, which was not observed in cases with delayed effects of therapy.

[Prognostic criteria of efficacy of inhalation glucocorticosteroids in non-severe bronchial asthma].

The aim of the study was to evaluate efficacy of inhalation glucocorticosteroid (GCS) drugs in patients with persisting bronchial asthma (BA) previously steroid untreated and identify factors influencing the results of GCS therapy. 67 patients with non-severe BA given long-term theophilline with inadequate effect received inhalation GCS drug budesonid which produced a complete clinical effect (group 1), a delayed effect (group 2) or no effect (group 3). The above groups were compared by clinico-anamnestic data, functional respiration parameters, chemiluminescence of mononuclear cells of the peripheral blood measured before therapy with budesonide.