[The effect of tefestrol on the secretion of luteinizing hormone from the hypophysis].

The effect of tefestrol on the content of luteinising hormone in blood and hypophysis in female and male rats was studied on the basis of the radioimmunological assays. It was shown that administration of tefestrol to the female rats depending on the preparation dose and the time of administration during the estrous cycle can produce an increase and a decrease of luteinising hormone content in the material under study. In the male rats tefestrol induced a stable elevation of blood gonadotropine level.

[Modulating effect of estradiol on the sensitivity of the preoptic area neurons to noradrenaline].

Sensitivity of the preoptic area neurons to norepinephrine before and after application of estradiol was investigated. The obtained results show that estradiol influences neuron sensitivity. Microiontophoretic application of norepinephrine followed the estradiol into the preoptic area and increased the activity of single neurons in the majority of experiments.

[Treatment of patients with disorders of the ovulatory function of central etiology with preparations affecting adrenergic mechanisms].

A treatment protocol has been proposed for patients with luteal phase inadequacy of central origin employing isodrin stimulation of beta-adrenergic receptors on days 5 to 10 of the cycle and fetanol stimulation of alpha-adrenergic receptors on days 10 to 14. This protocol is recommended for use in ovarian function normalization, both alone and in combination with hormonal therapy.

[Estrogen-sensitive neurons of the preoptic area of the hypothalamus].

Microiontophoretic application of estradiol to the preoptic area of the hypothalamus enhanced the unit activity, the response being more obvious at the diestrus-2 stage and owing to the level of endogenous estrogens.

[Changes in the gonadotropic function of the rat hypophysis during development of experimental alcoholism].

Luteinizing hormone (LH) and prolactin blood plasma levels and LH level in the pituitary of alcoholic male rats were studied Alcoholic rats (heavy drinkers) have revealed hyperprolactinemia and inadequate LH secretions. The possible role of gonadotropins in the development of hypogonadism in alcoholic rats is discussed.