Human Melanoma and Glioblastoma Cells Express Cathepsins Supporting Reovirus Moscow Strain Infection.

This study evaluates the oncolytic potential of the Moscow strain of reovirus against human metastatic melanoma and glioblastoma cells. The Moscow strain effectively infects and replicates within human melanoma cell lines and primary glioblastoma cells, while sparing non-malignant human cells. Infection leads to the selective destruction of neoplastic cells, mediated by functional viral replication.

[Sensitivity of Primary Human Glioblastoma Cell Lines to the Mumps Virus Vaccine Strain].

The sensitivity of human glioblastoma cells to virus-mediated oncolysis was investigated on five patient-derived cell lines. Primary glioblastoma cells (Gbl13n, Gbl16n, Gbl17n, Gbl25n, and Gbl27n) were infected with tenfold serial dilutions of the Leningrad-3 strain of the mumps virus, and virus reproduction and cytotoxicity were monitored for 96-120 h. Immortalized human non-tumor NKE cells were used as controls to determine the virus specificity.

The Study of Effectiveness of Combined Proton-Neutron Irradiation of Tumor Cells In Vitro.

Combined proton-neutron therapy can be the best opportunity for neutron radiation therapy due to highly conformal proton irradiation and high relative biological effectiveness of neutrons. The study compares 4 schemes of sequential in vitro exposure of Chinese hamster fibrosarcoma cells B14-150 to 14.5 MeV neutrons and a scanning beam of protons.

Third harmonic of the dynamic magnetic susceptibility of a concentrated ferrofluid: Numerical calculation and simple approximation formula.

Information about the nonlinear magnetic response of dispersions of magnetic particles is the basis for biomedical applications. In this paper, using analytical and numerical methods, the third harmonic of the dynamic susceptibility of an ensemble of moving magnetic particles in an ac magnetic field with an arbitrary amplitude is studied, taking into account interparticle interactions. A simple approximation formula is proposed to predict the third harmonic as a function of two parameters: the Langevin susceptibility χ_{L}, which is used to estimate the particle dipole-dipole interactions, and the Langevin parameter ξ, which represents the ratio of the energy of the magnetic moment interacting with the magnetic field to the thermal energy.