[Endotoxin tolerance of mice to the effect of lipopolysaccharide and lipopolysaccharide-mice toxin complex of virulent strain Yersinia pestis 231].

Aim: Comparative study of the effect of endotoxin tolerance of mice to the effect of lipopolysaccharide (LPS37) and complex of lipopolysaccharide with mice toxin (LPS37-MT) of a virulent Yersinia pestis 231 strain.

Materials And Methods: Preparations of LPS of highly virulent strain Y. pestis 231 obtained by phenol method from cells cultivated at 37 degrees C as well as commercial preparations of S-LPS and R-LPS of Escherichia coli were used.

[Toxicity and cytokine-inducing activity of lipopolysaccharide of virulent Yersinia pestis 231 strain].

Aim: Determine correlation between toxicity and cytokine inducing activity of parent and conformation modified forms of lipopolysaccharides (LPS) of virulent Yersinia pestis strain.

Materials And Methods: LPS was isolated by phenol method from Y. pestis 231 cells grown at 37 degrees C (LPS37).

[Toxicity of Yersinia pestis EV76 lipopolysaccharides for mice sensitized by D-galactosamine].

Aim: To study toxicity of lipopolysaccharides (LPS28 and LPS 37) of Yersinia pestis for mice sensitized by D-galactosamine (D-GalN).

Materials And Methods: LPS were obtained by the Westphal method from Y. pestis EV76 strain grown at temperatures of 28 and 37 degrees C.

[Effect of Yersinia pestis EV 76 lypopolysaccharides with different levels of toxicity on dynamics of TNF-alpha and INF-gamma synthesis by human monocytes].

Unlabelled: AIM. To study dynamics of synthesis of TNF-alpha and INF-gamma by cell line U-937 human monocytes under the effect of Yersinia pestis EV 76 lypopolysaccharides (LPS) with different levels of toxicity: original LPS28 and LPS37 as well as their conformationally--changed variants with enhanced toxicity--complex of LPS with murine toxin (MT) of Y. pestis, and LPS modified by biologicall active compound (BAC) obtained from human erythrocytes.

[Possible mechanisms of implementation of toxic potential of lipopolysaccharides of pathogenic bacteria].

The significance of variability of biological properties of lipopolysaccharides (LPS) is discussed in the paper within the pathogenesis of infectious process. On the basis of an analysis of published data and of results of independent research of two microorganisms (Yersinia pestis and Francisella tularensis) a conclusion is made on that a biologically inert LPS form (with a weak cytokine-inducing ability, apirogenicity and non-toxicity etc.) is typical of highly pathogenic bacteria.