Assessment of the Status of Effector and Regulatory Components of Immune System in Chelyabinsk Region Residents Exposed to Radiation Due to Residence in the Area Contaminated as a Result of the Radiation Accident at Mayak PA and in Their Offspring.

Immune status was studied in the framework of the current work and the results of the analysis of concentration of 26 characteristic parameters of innate and acquired immunity in 140 individuals from 56 trios (fathers, mothers and their Ist generation offspring that were included in 2 groups) are presented. Fathers and mothers of the children under study in the main groip Were exposed due to a long-term residence (from childhood to maturity) in the areas of Chelyabinsk region contaminated as a result of the-accident at Mayak PA (contamination included long-lived isotopes - ⁹⁰Sr and, to a smaller extent, ¹³⁷Cs and ²³⁹Pu) and then migrated into Ozyorsk prior to the conception of their children (75 individuals, 33 family trios). Comparison group (control) included parents and their offspring who are Ozyorsk residents never residing in the areas contaminated by radionuclides (65 individuals, 23 family trios).

[SYNERGISM OF PRECONCEPTIVE RADIATION EXPOSURE AND PARENTS' ONCO-PATHOLOGY IN THE RISE OF CARCINOGENIC RISK IN THE OFFSPRINGS OF PROFESSIONAL EMPLOYEES].

The problem of carcinogenic risk in offsprings of individuals exposed to radiation is challenging and insufficiently studied. In that there are no evaluations of the interaction between radiation and non-radiation factors. The aim of the study was the analysis of interaction of preconceptive radiation exposure and parents' onco-pathology in cancer mortality in offsprings (F1) of workers (fathers) of the Mayak Production Association exposed to a wide range of doses of radiation over a year prior conception.

[PLUTONIUM AND LIFETIME REDUCTION AMONG PROFESSIONAL WORKERS FSUE].

The objective of the study is the assessment of lifetime in the cohort of Mayak PA workers employed in 1948-1958 and exposed to incorporated Pu-239. The decrease of age at death 5.2 years among males and 6.

Restriction on the energy and luminosity of e(+)e(-) storage rings due to beamstrahlung.

The role of beamstrahlung in high-energy e(+)e(-) storage-ring colliders (SRCs) is examined. Particle loss due to the emission of single energetic beamstrahlung photons is shown to impose a fundamental limit on SRC luminosities at energies 2E(0)≳140  GeV for head-on collisions and 2E(0)≳40  GeV for crab-waist collisions. With beamstrahlung taken into account, we explore the viability of SRCs in the 2E(0)=240-500   GeV range, which is of interest in the precision study of the Higgs boson.

[Interaction of genetic and radiation factors in the realization of effects of radiation in humans].

The results of the study of the interaction of genetic and radiation factors in the effects of radiation in humans exposed to external and (or) internal radiation are presented. In most cases, with relatively less radiation exposure genotypic differences in the effects of exposure were established to be absent. At high intensities of radiation exposure, however, these differences as a rule have reliable character.