[PLUTONIUM AND LIFETIME REDUCTION AMONG PROFESSIONAL WORKERS FSUE].

The objective of the study is the assessment of lifetime in the cohort of Mayak PA workers employed in 1948-1958 and exposed to incorporated Pu-239. The decrease of age at death 5.2 years among males and 6.

[Interaction of genetic and radiation factors in the realization of effects of radiation in humans].

The results of the study of the interaction of genetic and radiation factors in the effects of radiation in humans exposed to external and (or) internal radiation are presented. In most cases, with relatively less radiation exposure genotypic differences in the effects of exposure were established to be absent. At high intensities of radiation exposure, however, these differences as a rule have reliable character.

[The parameters of genetic variability and of selection in offsprings of exposed humans].

Mayak workers offsprings parameters of genetic variability including heterozygosity, genetic combinations, quantitative characteristics of genetic class reproduction, genetic identity and intervals, and parameters of selection including relative adaptation of genetic classes and mean adaptation depending on preconceptive doses of parents' exposure were studied. Genetic markers of Mayak workers, their children and grandchildren were defined. Children whose parents had preconceptive doses of more than 200 cGy in comparison with the control group had the heterozygosity reduction by Hp system and tendency to the mean heterozygosity reduction studied genetic system.

[Distribution of genetic markers in offsprings of irradiated individuals].

For the estimation of radiation exposure on genetic processes in Mayak PA population we studied the distribution of a number of genetic markers in offsprings of Mayak PA workers depending on radiation (preconceptive and antenatal chronic exteral gamma-radiation) and non-radiation (age-sex characteristics of children and age characteristics of parents to the moment of conception) factors. Relatively unfavorable changes in distribution of genotypes and genes of haptoglobin genetic system in offsprings, whose parents (one or both) were exposed to external gamma-radiation in preconceptive cumulative dose of more than 200 cGy were detected. The most obvious reason of such changes may consist in directed gametic selection (Hp2 allele versus Hp1 allele) which turns out in abnormalities of segregation of Hp2-1 heterozygote that have both alleles.

[Some health parameters in personnel contacting highly enriched uranium].

The authors analysed 20-years and longer observations over health state of personnel having occupational contact with highly enriched uranium. Findings are no determined effects as clinical manifestations of chronic uranium intoxication, presented by most frequently involved systems (hemopoietic, bronchopulmonary) and main organs accumulating uranium (liver, kidneys, bones). Long-term observations revealed malignancies in 11% of the examinees.