[The physiological characteristics of the antioxidant properties of Lipin in bronchial asthma in children].

In children of 4-7 years old with bronchial asthma (BA) has been studied the values of lipid peroxidation, antioxidant status and some others in blood plasma and erythrocytes without and with the use of new drug Lipin. It was shown that in children with BA the malondialdehyde concentration increased, the superoxydedismutase activity decreased, the NAD concentration increased, and the ratio of superoxidedismutase/malondialdehyde greatly decreased in comparison with normal children. The use of Lipin led to diminuation of lipid peroxidation, to marked increase of superoxidedismutase activity, to decrease of NAD concentration, and to significant increase of superoxidedismutase/malondialdehyde ratio.

[Pathophysiologic mechanisms of cardiorespiratory system dysfunction in high school children with chronic obstructive pulmonary diseases].

The basic indices of the cardiorespiratory system function, gas exchange, regional pulmonary functions have been studied. It is stated that a group of children with a higher level of oxygen consumption (hyperergic type) as against a control group is characterized by disorder in permeability of terminal branches of a bronchial tree, by the development of acute obstructive emphysema, increase in alveolar ventilation with relative decrease in minute blood volume, arterial hypoxemia with possible emergence of tissue hypoxia. A decrease in permeability of large bronchi were observed in a group of children with a low level of oxygen consumption (hypoergic type).