Organophosphorus -adenosyl--methionine mimetics: synthesis, stability, and substrate properties.

-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the -methyl group are widely used to study these processes. However, many of these analogs are chemically unstable that largely limits their practical application.

Synthesis and Biological Evaluation of a Series of New Hybrid Amide Derivatives of Triazole and Thiazolidine-2,4-dione.

A series of hybrid compounds with triazole and thiazolidine nuclei connected by a linker has been synthesized and extensively studied. Various synthetic methods for the target compounds have been tested. A microbiological assessment of the obtained compounds was carried out on strains of pathogenic fungi , , multidrug-resistant , , spp.

Pyrrolidine/Azepane Ring Expansion via Intramolecular Ullmann-Type Annulation/Rearrangement Cascade: Synthesis of Highly Functionalized 1-Benzazepines.

5-Arylpyrrolidine-2-carboxylates with an -halogen substituent at 5-aryl and an electron-withdrawing group at the C position of the pyrrolidine ring were transformed into 1-benzo[]azepine-2-carboxylates under Cu(I) promotion and microwave activation. Reaction promoter copper(I) thiophene-2-carboxylate has been generated in the reaction's environment from CuO and thiophene-2-carboxylic acid. Functionalized 1-benzo[]azepine-2-carboxylates were obtained in racemic and optically active forms in 67-89% yields.

Zn-dependent β-amyloid Aggregation and its Reversal by the Tetrapeptide HAEE.

The pathogenesis of Alzheimer's disease (AD) is associated with the formation of cerebral amyloid plaques, the main components of which are the modified Aβ molecules as well as the metal ions. Aβ isomerized at Asp7 residue (isoD7-Aβ) is the most abundant isoform in amyloid plaques. We hypothesized that the pathogenic effect of isoD7-Aβ is due to the formation of zinc-dependent oligomers, and that this interaction can be disrupted by the rationally designed tetrapeptide (HAEE).