Genetic and Epigenetic Sexual Dimorphism of Brain Cells during Aging.

In recent years, much of the attention paid to theoretical and applied biomedicine, as well as neurobiology, has been drawn to various aspects of sexual dimorphism due to the differences that male and female brain cells demonstrate during aging: (a) a dimorphic pattern of response to therapy for neurodegenerative disorders, (b) different age of onset and different degrees of the prevalence of such disorders, and (c) differences in their symptomatic manifestations in men and women. The purpose of this review is to outline the genetic and epigenetic differences in brain cells during aging in males and females. As a result, we hereby show that the presence of brain aging patterns in males and females is due to a complex of factors associated with the effects of sex chromosomes, which subsequently entails a change in signal cascades in somatic cells.

A New Cofilin-Dependent Mechanism for the Regulation of Brain Mitochondria Biogenesis and Degradation.

Unlabelled: Was to study the role of post-translational modifications of cofilin in the regulation of respiration and autophagy in murine brain mitochondria.

Materials And Methods: The experiments were performed with C57BL/6 mice. To obtain cytoplasmic and mitochondrial fractions of the brain tissue, differential centrifugation was used.

Enzymatic Digestion of Hyaluronan-Based Brain Extracellular Matrix Can Induce Seizures in Neonatal Mice.

It is well-known that hyaluronic acid (HA) as a component of brain extracellular matrix (ECM) plays a pivotal role in the nervous system and is involved in synaptic plasticity changes in vascular cognitive impairment and dementia. HA breakdown is a feature of the acute stage of stroke injury and may be detrimental through enhancement of the inflammatory response. Recent studies have shown that knockout mice lacking hyaluronic acid synthetase demonstrates epileptic phenotype and removal of HA leads to delayed development of epileptiform activity in cultured hippocampal neurons .

Sporicidal efficacy of thermal-sprayed copper alloy coating.

Approximately 200 000 Canadians acquire healthcare-associated bacterial infections each year and several-fold more acquire food-borne bacterial illnesses. Bacterial spores are particularly problematic because they can survive on surfaces for several months. Owing to its sporicidal activity, copper alloy sheet metal is sometimes used in hospital settings, but its widespread use is limited by cost and incompatibility with complex furniture and instrument designs and topographies.

[Organizational and therapeutic aspects of the elimination of the medical consequences of chemical accidents].

During the liquidation of consequences of chemical accidents the main task is minimization o the population losses and the provision of effective medical care to. the victims. Training experience related to chemical accidents, shows the need for constant readiness of health facilities in the area of the chemical industry accommodation, planning of the medical forces and resources reserve.