[Diagnostic value of studies of amino acid metabolism during prolonged contact with pesticides].

Amino acid metabolism was studied experimentally during prolonged administration of a mixture of organochlorine, -metallic, and -phosphorus pesticides and in subjects occupationally exposed to pesticides for a long time. A marked increase of blood serum and liver levels of ser, glu, gly, ala, val, isolei, tyr, phen and a decrease of cystine were detected in white rats. Blood serum serine and threonine hydratases activities increased in parallel with increase of pesticide mixture dose.

[The trypsin-antitrypsin system and the content of blood middle-molecular peptides in experimental traumatic shock].

It was established that the activity of trypsin and the content of its inhibitors--alpha 1-inhibitor of proteinases and alpha 2-macroglobulin--undergo phase changes of different meaning and direction with the gradual development of traumatic shock. The character of these changes indicates that trypsinemia is an important pathogenetic link of traumatic shock and corresponds to its severity. The compensatory activation of the trypsin inhibitors is directed to increasing the resistance of the body to trypsinemia.