[The use of verapamil for correcting the hemodynamic disorders in the acute period of a myocardial infarct].

A study of 40 patients with acute myocardial infarction indicates that in those without circulatory insufficiency phynoptin did not reduce cardiac ejection but reduced postloads, energy expenditures and work of the left ventricle myocardium, favoured early stabilization of the cardiovascular system. In cases with cardiac insufficiency phynoptin reduced the contractile capacity of the left ventricle, stasis in the lesser circulation. Associated use of phynoptin and nitrates in acute myocardial infarction with circulatory insufficiency allowed to avoid depressive effect of phynoptin on myocardial contractility and to avoid progression of cardiac insufficiency.

[The use of naniprus (sodium nitroprusside) in therapy-resistant arterial hypertension].

Naniprus (sodium nitroprusside) was shown to be clinically effective in the treatment of arterial hypertension and to have a favourable effect on the central and peripheral hemodynamics (a decrease of the total peripheral vascular resistance, of the energy consumption by the myocardium, an increase of the stroke volume, stroke index, and cardiac output). It is concluded that naniprus can be used for arterial pressure correction in the treatment-resistant patterns of hypertension, especially in combination with beta-blockers preventing the "after-action effect" (ejection at the moment of catecholamine infusion discontinuance).