Discovery and Optimization of a Compound Series Active against , the Causative Agent of Chagas Disease.

Chagas disease is caused by the protozoan parasite . It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Chagas disease is not satisfactory, and there is a need for new treatments.

[Psychological resources of coping with somatic illness in adolescents].

Objective: Introduction: Somatic illness, objectively and subjectively, can become a difficult life situation for a person. The adolescent's experience of illness is determined by the specifics of a particular age period. To develop an effective rehabilitation program, it is necessary to study the personal characteristics of the adolescent and his social environment, which may be resourceful.

Risk of colorectal cancer in ulcerative colitis in India.

Background: The risk for colorectal cancer (CRC) in ulcerative colitis (UC) in India is not known.

Method: Retrospective cohort from a tertiary level hospital in South India. Analysis of archived records of all patients with UC who underwent colonoscopy and segmental biopsies over the last 25 years.

Vascular changes in duodenal mucosa in shigellosis and cholera.

Vascular endothelial cells are highly specialized cells with numerous sensory and modulator functions. Our previous studies show extensive microvascular changes in rectal mucosal vasculature of patients with acute infective diarrhea (Mathan and Mathan 1985a, Gut 26:710-717). We looked for changes in the duodenal mucosal vasculature in two naturally occurring diarrheal infections: shigellosis and cholera.

Faecal lactoferrin as a predictor of positive faecal culture in south Indian children with acute diarrhoea.

Faecal lactoferrin, an iron-based glycoprotein found concentrated in secondary granules of neutrophils, may serve as a surrogate marker of inflammation in the intestine. We evaluated the usefulness of faecal lactoferrin as a predictor of infection with invasive enteropathogens in 262 children with diarrhoea. Lactoferrin at a dilution of 1:50 had the highest sensitivity for detection not only of conventionally cultured invasive enteropathogens but also of all other enteropathogens.