Publications by authors named "V I Marchenko"
Article Synopsis
- A(H5Nx) avian influenza viruses are widespread and evolving, with a notable emergence of highly pathogenic A(H5N1) clade 2.3.4.4b reassortant viruses since 2020.
- Some of these viruses, particularly those isolated from mammals, carry a mutation (E627K) in the PB2 protein that enables adaptation to mammalian cells.
- Recent findings from Russia reveal a highly pathogenic A(H5N1) virus with the E627K mutation that shows increased virulence in mice and limited airborne transmission in ferrets, underscoring the need for ongoing surveillance to mitigate pandemic risks.
Article Synopsis
- Equine piroplasmosis (EP) is a serious global infection that can be fatal to horses, with this study focusing on its presence in Siberia, Russia, where data was previously lacking.
- Blood samples from 750 horses across three regions in Siberia revealed that Theileria equi was present in 60.4% and Babesia caballi in 7.2% of the samples, indicating a significant prevalence of these pathogens.
- Genetic analysis showed T. equi was mainly of two genotypes, while B. caballi exhibited high genetic diversity with seven variants found, leading to the identification of new genetic clusters that have broadened existing knowledge about this pathogen's diversity.
Construction of Composite Correlation Index Matrix and Analysis of Cultural Properties of Representatives of Mycobacterium abscessus Complex Isolated from Patients with Cystic Fibrosis.
Int J Mycobacteriol
April 2024
Background: Microbiological diagnosis of mycobacteriosis is often difficult, as it is necessary to differentiate between transient colonization and active infection.
Methods: We studied the cultural properties of Mycobacterium abscessus complex (MABSc) strains obtained from cystic fibrosis patients, and also analyzed composite correlation index (CCI) values in patients with repeated MABSc inoculation and their correlation with the presence of clinical and radiological manifestations of mycobacteriosis.
Results: As a result, MABSc more often grew in S-form colonies in patients without clinical manifestations of chronic infection, while R-form colonies were characteristic of patients with chronic infection and clinical symptoms.
Background: Nutritional status's role in long COVID is evident in the general population, yet unexplored in patients undergoing hemodialysis (HD), posing a research gap. We hypothesized that pre-infection undernutrition in HD patients might impact long COVID persistence by accelerating oxidative stress. The present study aimed to investigate the association between pre-infection nutritional status, oxidative stress, and one-year-long COVID persistence in HD patients.
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- The H5N8 avian influenza virus poses a risk to bird populations and potential human health concerns, necessitating the development of a safe and effective vaccine.
- Researchers created an experimental pVAX-H5 DNA vaccine that encodes a modified version of the virus's hemagglutinin and tested it on mice, resulting in a strong antibody and T-cell response.
- Both liquid and lyophilized versions of the pVAX-H5 vaccine provided complete protection for mice against lethal influenza A virus challenges, showing promise as a candidate for combating H5N8.