Publications by authors named "V I Lyudyno"
Neuronal factor semaphorin-3A is viewed as immune suppressant of peripheral T lymphocytes, but it can also negatively affect activity of the thymus, the central organ of the immune system. The study examined the effects of this factor on proliferative activity and apoptosis of mouse thymocytes in vitro. Semaphorin-3A inhibited spontaneous and mitogen-stimulated proliferative activity of thymocytes producing no effect on the development of apoptosis in these cells.
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- The study examined how blocking galanin receptors affects anxiety in rats that experienced psychogenic trauma, created by witnessing a partner's death.
- Administering a galanin receptor antagonist before stress exposure heightened the rats' anxiety and led to behaviors like hypervigilance.
- The findings indicate that galanin plays a protective role in regulating the central nervous system's response to traumatic stress, which could relate to posttraumatic stress disorder.
The role of the neuropeptide galanin in forming type-specific behavioral characteristics.
Neurosci Behav Physiol
January 2008
Article Synopsis
- Intranasal administration of a galanin receptor blocker in rats resulted in decreased movement and increased anxiety when placed in a new environment.
- Higher levels of galanin precursor mRNA were found in the anterior hypothalamus of rats showing active behavior during open field tests.
- The blockade of galanin receptors led to a quicker rise in serum corticosterone during stress, indicating galanin's role in individual behavioral traits and stress adaptation.
The effects of interleukin-1beta at low, subpyrogenic doses on behavior were studied in rats. Signs of increased anxiety were evident by day 5 of treatment courses. These results provide evidence supporting the role of proinflammatory cytokines in the pathogenesis of emotional disorders.
View Article and Find Full Text PDFVascular endothelial growth factor is not only angiogenic, but also immunoregulatory factor. For evaluation of the possibility of its direct interaction with mouse thymocytes we studied the effect of vascular endothelial growth factor on proliferation and apoptosis of thymocytes and expression of genes for the corresponding receptor on these cells. Vascular endothelial growth factor modulated mitogen-induced proliferation of thymocytes and stimulated spontaneous apoptosis in intact thymus cells.
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