[Experimental and clinical studies of coronary circulation after administration of mildronate].

In experiments on dogs, application of the cross-over circulation method revealed that mildronate increased coronary blood flow due to active coronary dilation. In experiments on cats, a cardioprotective effect of mildronate was found, which prevented the development of acute ischemic heart failure by stabilizing the major hemodynamic parameters. Clinical studies of patients with Functional Classes I-III angina provided evidence for positive effects of mildronate on coronary blood flow.

[Adaptive reserves of the myocardium in patients with ischemic heart disease].

Myocardial adaptive reserves and their relation to the function of the adrenocorticohypophyseal system were examined in 69 patients with coronary heart disease. To define the adaptation of the myocardium during exercise, the index of myocardial adaptation was used. The function of the adrenocorticohypophyseal system was judged from blood levels of somatotropic hormone and cortisol before, at the peak, and 2 hours after exercise testing.

[Adaptive capacity of the myocardium in middle-aged and elderly persons].

Myocardial activity was evaluated in 165 individuals between 60 and 82 years of age. Only one parameter, myocardial stress adaptation index (MSAI), was shown to differ significantly between individuals. An earlier diagnosis of coronary heart disease was not confirmed in 43 (26.

[Indicators of scintigraphy using technetium Tc 99m pyrophosphate in angina pectoris in relation to the activity of the pituitary-adrenal system].

The effect of exercise on the parameters of the scintigraphy of the myocardium with labelled pyrophosphate was studied in 35 patients with coronary heart disease and angina of effort and at rest with regard to the activity of the pituitary-adrenal cortex system. The functional status of this system was evaluated on the basis of data on the blood changes in somatotrophic hormone and cortisol. The use of a scoring system made it possible to identify four types of the pattern of the scintigraphic parameters.

[Phenomenon of pyrophosphate accumulation in the prognosis of different forms of ischemic heart disease].

The results of pyrophosphate 99mTc scintigraphy of the myocardium during exercise were compared with the parameters of the tolerance and adaptation to the load and the frequency of manifestations of myocardial ischemia during bicycle ergometry in relation to the prognostic value with regard to coronary heart disease (CHD) development. The studies involved 21 patients with myocardial infarction at the early recovery period and 23 CHD patients without a history of myocardial infarction. Manifestations of myocardial ischemia and the pattern of pyrophosphate build-up in the myocardium during exercise are approximately equally informative with regard to the prognosis of a high risk of complications in CHD patients.