Publications by authors named "V I Kuz'min"
Article Synopsis
- The study focuses on understanding the complex physics of high-temperature superconducting cuprates through strong electronic interactions and introduces cluster perturbation theory (CPT) as a method to analyze these materials.
- Two specific CPT methods, spin-CPT and charge-CPT, were developed to examine dynamic spin and charge susceptibilities, utilizing exact diagonalization to include correlation effects.
- The research found that in underdoped cuprates, there are distinct spin excitation features at the (π,π) wave vector, while in overdoped cuprates, a low energy response appears at multiple incommensurate wave vectors, aligning with experimental observations from inelastic neutron scattering.
Cardiac-specific microRNA miR-133a-3p modulates adrenergic signaling. Adrenergic receptors and their intracellular pathways are the key players in proarrhythmic ectopy derived from the myocardial sleeves of the pulmonary veins. We studied the effect of miR-133a-3p on ectopy induced by norepinephrine in myocardial tissue of rat pulmonary veins.
View Article and Find Full Text PDFWe review the development and application of the Simplex approach for the solution of various QSAR/QSPR problems. The general concept of the simplex method and its varieties are described. The advantages of utilizing this methodology, especially for the interpretation of QSAR/QSPR models, are presented in comparison to other fragmentary methods of molecular structure representation.
View Article and Find Full Text PDFWe studied the influence of blockers of muscarinic M1, M2, and M3 receptors on the effect of acetylcholine in the myocardial tissue of caval veins in rats at the early stage of ontogeny. The experiments were performed on isolated preparations of the right superior vena cava working under their own rhythm. Action potentials were recorded using the standard microelectrode technique.
View Article and Find Full Text PDFA series of 60 nitrobenzonitrile analogues of the anti-viral agent MDL-860 were synthesized (50 of which are new) and evaluated for their activity against three types of enteroviruses (coxsackievirus B1, coxsackievirus B3 and poliovirus 1). Among them, six diaryl ethers (20e, 27e, 28e, 29e, 33e and 35e) demonstrated high in vitro activity (SI > 50) towards at least one of the tested viruses and very low cytotoxicity against human cells. Compound 27e possesses the broadest spectrum of activity towards all tested viruses in the same way as MDL-860 does.
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