Association between effectiveness of tuberculosis treatment and cytochrome P-4502E1 polymorphism of the patients.

Context: The risk of antituberculosis (TB) drug-induced liver injury could be determined by patients' genotype polymorphism of the xenobiotic-metabolizing enzymes. To find the meaning of cytochrome P-4502E1 (CYP2E1) polymorphism in TB patients. Corresponding of CYP2E1 polymorphism in TB patients with the level of isoniazid and rifampicin as well as for the outcome and toxicity development during inpatient TB treatment.

[Not Available].

The investigation objective was to estimate the peritoneal adhesions formation risk in children with phenotypic signs of the connective tissues dysplasia (CTD—syndrome). On the first stage the formalized phenotypic clinical signs were estimated in accor' dance to χ2 Pearson criteria (p<0.05).

[Clusters of Mycobacterium tuberculosis Genotypes in Odesa Region].

It has been studied a genotype of 104 strains of Mycobacterium tuberculosis, obtained from sputum of patients with tuberculosis (TB), via detection of six loci VNTR (Variable Number Tandem Repeats), which are characterized by highest polymorphism - MIRU10, MIRU26, MIRU31, MIRU39, MIRU40, ETR-A. According to received data in Odesa region one can see further increasing of spreading of Beijing family strains that are characterized by unfavourable course of TB and high drug-resistance. Polymorphism of certain detected loci of M.

[Polymorphism of the biotransformation gene--cytochrome-450 2C9 in the patients with tuberculosis].

The goal of this work was to study cytochrome-450 (CYP) 2C9 (CYP2C9) gene polymorphism in patients with tuberculosis (TB) and its meaning for development, progress, and outcome of TB, for the pharmacokinetics of the antituberculosis antibiotic rifampicin on the basis of the southern region of Ukraine. Among the TB patients it was 24.9% less than in carriers of the genotype *1/*1 and than in healthy donors.

Alternative genotyping of drug-resistant Mycobacterium tuberculosis strains.

The aim of the present research was to study the capability of a genotyping method for M. tuberculosis through detection of six VNTR-loci (MIRU10, MIRU26, MIRU31, MIRU39, MIRU40, ETR-A). Loci MIRU10, MIRU26, MIRU40 and ETR-A have exhibited high polymorphism in group non-Beijing, while loci MIRU26 and MIRU31 - in the Beijing family.