Publications by authors named "V I Korchagin"
The purpose of this study was to determine the contribution of genetic factors, i.e., the level of expression and polymorphisms of Toll-like receptors (TLR), to the susceptibility of latent tuberculosis infection in a Russian cohort of individuals infected with HIV.
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- - The study focuses on the diploid parthenogenetic lizard Darevskia unisexualis, which is a hybrid derived from two parental species, offering insights into sexual and asexual reproduction mechanisms.
- - Researchers conducted a detailed analysis of the pericentromeric DNA sequences of the parental lizards, revealing unique species-specific sequences that helped create fluorescent probes to distinguish parental chromosomes in the hybrid.
- - The team developed a computational method to find species-specific fluorescent probes for studying pericentromeres, laying the groundwork for future research on hybrids in both nature and labs.
The polymorphism of SINE-containing loci reflects the evolutionary processes that occurred both during the period before the divergence of the taxa and after it. Orthologous loci containing SINE in two or more genomes indicate the relatedness of the taxa, while different copies may have a specific set of mutations and degree of difference. Polymorphic insertion can be interpreted with a high degree of confidence as a shared derived character in the phylogenetic reconstruction of the history of the taxon.
View Article and Find Full Text PDFGenetic factors in the HIV-background may play a significant role in the susceptibility to secondary diseases, like tuberculosis, which is the leading cause in mortality of HIV-positive people. Toll-like receptors (TLRs) are considered to be receptors for adaptive immunity, and polymorphisms in TLR genes can influence the activity of the immune response to infection. We conducted a case-control study of the association of TLR gene polymorphisms with the risk of tuberculosis coinfection in a multi-country sample of HIV-positive participants.
View Article and Find Full Text PDFBackground: The progression of infectious diseases depends on the characteristics of a patient's innate immunity, and the efficiency of an immune system depends on the patient's genetic factors, including SNPs in the genes. In this pilot study, we determined the frequency of alleles in these SNPs in a subset of patients with pneumonia.
Methods: This study assessed six SNPs from genes: rs5743551 (), rs5743708, rs3804100 (), rs4986790 (), rs5743810 (), and rs3764880 ().